Sevoflurane in COVID-19 ARDS (SevCov)

Status Completed

Clinical Trial Summary

The purpose of this trial is to study the effect of initial temporary sevoflurane sedation on mortality and persistent organ dysfunction (POD) in survivors at day 28 after ICU admission in the population of patients suffering from COVID-19 ARDS.

Clinical Trial Description

The corona virus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is spreading rapidly across Europe. While data from European centers are still missing, several publications from Chinese centers are available. Respiratory failure from acute respiratory distress syndrome (ARDS) is the leading cause of mortality, and may be caused or exacerbated by a 'cytokine storm syndrome'. Recent trials from our group demonstrated that the volatile anesthetic sevoflurane administered during ventilation of patients has anti-inflammatory properties. Moreover, in in vivo studies volatile anesthetics reduce the severity of ARDS compared to intravenous sedation, which has been confirmed in a clinical pilot trial. Attenuating ARDS and thereby improving oxygenation strongly decreases morbidity and mortality of patients. ;

Study Design

Related Conditions & MeSH terms

ARDS, Human
Coronavirus
Respiratory Distress Syndrome, Adult

Clinical Trial Details

NCT number	NCT04355962
Study type	Interventional
Source	University of Zurich
Contact
Status	Completed
Phase	Phase 3
Start date	April 23, 2020
Completion date	July 16, 2021

View Details

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