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NCT05175495 Clinical Trial

Influencing Factors of Coronary Heart Disease in Young People

Coronary Heart Disease Clinical Trial

Official title:
To Study the Risk Factors of Youth Coronary Heart Disease From Inflammatory Cytokines，Lifestyle and Familial Inheritance

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05175495
Other study ID # Observational
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date August 1, 2021
Est. completion date August 1, 2024

Study information
Verified date July 2023
Source Affiliated Hospital of Nantong University
Contact hzh sheng, Dr.
Phone 13515203348
Email yjshz@ntu.edu.cn
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome

Description:

Through the multi-center clinical research conducted by several units in Nantong city, the risk factors and aggregation of the incidence of CHD among young people in nantong city were obtained, so as to fill in the blank of domestic multi-center research and reduce the incidence of CHD among young people.The investigators will conduct a long-term follow-up study on the young patients with CHD to screen the factors contributing to the poor prognosis of CHD in young patients.The investigators will fill this gap and intervene early to improve patients' quality of life and prolong their survival

Recruitment information / eligibility
Status Recruiting
Enrollment 1000
Est. completion date August 1, 2024
Est. primary completion date August 1, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria: - Diagnosed coronary heart disease - Confirmed by coronary angiography - Diagnosed myocardial infarction - Willing to sign an inform consent Exclusion Criteria: - Patients won't sign an inform consent or will not comply with the follow up.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China shengHz Nantong Jiangsu

Sponsors (2)
Lead Sponsor Collaborator
Hongzhuan Sheng Affiliated Hospital of Nantong University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Whether inflammatory factors are differentially expressed in young patients with coronary heart disease The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing. Until April 2024
Primary The effect of gene activity on youth morbidity The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene Until April 2024
Primary Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results Until April 2024
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