Coronary Disease and the Effect of High-intensity Interval Training

Coronary Disease Clinical Trial

— CENIT  

Official title:

Physical Activity and Lipid Content of Coronary Artery Atheromatous Plaques: a Randomised Trial Using Novel Intracoronary Imaging Techniques

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02494947
• Other study ID #: 2015/210
• Status: Completed
• Phase: N/A
• Start date: February 2016
• Est. completion date: April 2019

Study information

• Verified date: August 2019
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: April 2019
• Est. primary completion date: April 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• stable coronary artery disease

• will undergo cardiac catheterization

• will be treated with percutaneous coronary intervention (PCI)

• signed written informed consent

• able to execute the intervention

Exclusion Criteria:

• earlier bypass surgery

• known inflammatory disease other than atherosclerosis

• planned surgery within 4 months

• included in another randomized controlled study

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease

Intervention

Behavioral:
• high intensity interval-based aerobic exercise
Interval exercises done 3 times weekly during 6 months according to standard procedures at the Department of Circulation and Medical Imaging.

Other:
• Usual care

Locations

Country	Name	City	State
Norway	St Olavs Hospital	Trondheim

Sponsors (2)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology	St. Olavs Hospital

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	lipid content of atherosclerotic coronary artery plaques	Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy	6 months