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Clinical Trial Summary

Epicardial adipose tissue (EAT) is the visceral fat depot of the heart. EAT transcriptome is unique when compared to subcutaneous fat. EAT is a highly inflammatory tissue enriched with genes involved in inflammation, endothelial function, immune signaling and thermoregulation. EAT has been correlated with coronary artery disease (CAD) and atrial fibrillation (AF), although the mechanisms of the interplay of EAT with these two major cardiovascular diseases have not been fully understood.

Whether EAT may act as brown fat and whether this may be affected by the presence of CAD is currently unknown. Whether the postulated thermoregulatory function of the EAT is correlated to the presence and severity of CAD is unknown

EAT is though to play a role in the development and recurrence of AF. Recent studies showed that EAT has a unique transcriptome with genes encoding for pro-arrhythmogenic proteins. EAT is located in different areas of the heart. Whether regional EAT depots may have different genetic profile and functions is unknown. Whether peri-atrial EAT may have unique effects on cardiac muscle activity distinct from other EAT sub-depots is unknown.

Peri left atrial EAT and pericoronary EAT will be collected from patients who are undergoing elective cardiac surgery as standard care. EAT transcriptome will be analysed with RNA- sequencing analysis (RNA-seq) and quantitative real time polymerase chain reaction (qRT-PCR) . Immunofluorescence and immunoblot will be also performed on fat samples.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03693261
Study type Observational
Source University of Miami
Contact Gianluca Iacobellis, MD PhD
Phone 3052433636
Email giacobellis@med.miami.edu
Status Recruiting
Phase
Start date September 1, 2018
Completion date June 30, 2020

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