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Coronary Artery Disease clinical trials

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NCT ID: NCT05914246 Active, not recruiting - Clinical trials for Coronary Artery Disease

VIOLA Post Market Surveillance Clinical Protocol

Start date: July 5, 2023
Phase: N/A
Study type: Interventional

The goal of this post marketing surveillance clinical trial is to learn about VIOLA as a proximal seal device in patients undergoing coronary artery grafting (CABG) surgery. The main objective is to evaluate the clinical safety and performance of the VIOLA. Participants will be treated with routine CABG with use of VIOLA for maintaining hemostasis when suturing the proximal anastomosis. Patients will be followed for any clinical events at 6 weeks and 9 months post surgery.

NCT ID: NCT05913778 Active, not recruiting - Clinical trials for Coronary Artery Disease

Long-tErm Effects of Enhanced eXternal CountErpuLsation

EXCEL
Start date: December 10, 2020
Phase: N/A
Study type: Interventional

Enhanced external counterpulsation (EECP) is an effective non-invasive treatment in patients with coronary artery disease (CAD) which complicated by chronic heart failure (CHF). Aim: to study the long-term effects of treatment with enhanced external counterpulsation on the structural and functional state of the vascular bed in patients with stable CAD complicated by CHF. Patients (n=100) with verified stable CAD (class 2-3 angina) complicated by CHF (NYHA class 2-3) and receiving optimal drug therapy included in open randomized study. Primary randomization (2:1) + secondary randomization (1:1). - SHAM-counterpulsation group (ECP-SHAM; compression pressure 80 mm Hg; 35 procedures, 1 hour each); - Active counterpulsation group (ECP35; compression pressure 220-280 mm Hg; 35 procedures, 1 hour each) 1 course per year; - Active counterpulsation group (ECP70; compression pressure 220-280 mm Hg; 35 procedures, 1 hour each) 2 courses per year. Duration of observation is 3 years. Stages of examination: after 3, 6, 12, 24, 36 months (after 3, 6, 12 months for the ECP-SHAM group). Primary endpoint: combination of vascular event (myocardial infarction, acute cerebrovascular accident, revascularization procedures), hospitalization (for CAD/CHF), death. Secondary endpoints: changes in exercise tolerance, a needing for antianginal therapy, frequency of angina episodes. Objectives: to study the dynamics of the structural and functional state of the vascular bed (applanation tonometry, photoplethysmography, computer nailfold videocapillaroscopy), the dynamics of the clinical status (Clinical Status Assessment Scale), the dynamics of exercise tolerance (6-minute walk test), the dynamics of the quality of life of patients ( questionnaires SF36 and MLHFQ) in the ECP35 and ECP70 groups at baseline, at the end of the first course, after 6 months, 1, 2, and 3 years, and in the ECPSHAM group at baseline, at the end of the first course, after 6 and 12 months; (2) To investigate the impact of EECP on the incidence of primary (vascular events, hospitalizations for CAD/CHF, death) and secondary (frequency of angina episodes, need for antianginal drugs, exercise tolerance) endpoints. Expected outcome of the study: Obtaining reliable data on the long-term positive effect of EECP on the dynamics of the structural and functional state of the vascular bed, exercise tolerance, quality of life and prognosis in patients with stable CAD complicated by CHF.

NCT ID: NCT05891392 Active, not recruiting - Clinical trials for Coronary Reconstruction

Early Results Of Coronary Artery Reconstruction For Extensive Coronary Disease

Start date: January 1, 2022
Phase:
Study type: Observational

Evaluation of early outcome obtained from coronary reconstruction with or without endarterectomy in extensive diseased coronary arteries

NCT ID: NCT05888168 Active, not recruiting - Clinical trials for Coronary Artery Disease

Predictors of Postoperative Atrial Fibrillation After CABG

CODA-AF
Start date: January 1, 2018
Phase:
Study type: Observational

This observational study aims to identify the determinants or predictors of postoperative atrial fibrillation (POAF) in patients who have undergone coronary artery bypass grafting (CABG). The study will compare two cohorts: patients who developed POAF and those who did not (non-POAF), with the aim of improving postoperative care, reducing complications, and refining patient risk stratification.

NCT ID: NCT05874752 Active, not recruiting - Clinical trials for Coronary Artery Disease

Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work

Start date: October 1, 2021
Phase:
Study type: Observational

Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) myocardial function in symptomatic patients with coronary artery disease using the promising method. Methods: Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography. Images were stored and imported into the software for further offline analysis of PSL-based MW. MW analysis were carried out on each patient for global and regional myocardial function assessment.

NCT ID: NCT05843487 Active, not recruiting - Clinical trials for Coronary Artery Disease

Association Between Carotid Plaque Length and Cardiovascular Outcomes

Start date: January 1, 2017
Phase:
Study type: Observational

This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from January 2017 through December 2018.

NCT ID: NCT05841082 Active, not recruiting - Clinical trials for Coronary Artery Disease

Coronary Revascularization in Patients On Dialysis in China-Retrospective Registry

CRUISE-R
Start date: January 1, 2015
Phase:
Study type: Observational

Coronary artery disease (CAD) is the leading cause of death in end-stage renal disease (ESRD) patients requiring dialysis. There are limited data on clinical characteristics, treatment strategies and outcomes in this special patient population in China. As a nationwide, observational, multicenter cohort study, this study consecutively included ESRD patients on dialysis with significant CAD at 30 tertiary care centers in 12 provinces in China from January 2015 to June 2021. Patient data collected included demographics, comorbidities, cardiac history, cardiac function, location and severity of CAD, procedural information, medications, and clinical events.

NCT ID: NCT05787886 Active, not recruiting - Clinical trials for Acute Coronary Syndrome

Rotational Atherectomy: Long-term Results From a Single Center Experience

RA-BIA
Start date: May 1, 2022
Phase:
Study type: Observational [Patient Registry]

The RA-BIA Registry is a single-center observational study. The study included consecutive patients from 2008 who met inclusion criteria and were treated with RA. The main aim of the study is to assess the efficacy of rotational atherectomy.

NCT ID: NCT05772754 Active, not recruiting - Clinical trials for Coronary Heart Disease

Molecular Pathways Involved in Cardiac Remodeling in Patients With Chronic Heart Failure With Preserved Ejection Fraction by New Omics Technologies

HFpEF
Start date: December 18, 2020
Phase: Early Phase 1
Study type: Interventional

Heart failure with preserved ejection fraction nowadays affects about half of all patients with heart failure. In the general population, the prevalence of this subclass of heart failure (HFpEF, ed.) increases as the age of patients increases, especially in those over 65 years of age, and it has a significant gender. The study is to investigate the molecular pathways, predominantly protein patterns, involved in cardiac remodeling peculiar to heart failure with preserved ejection fraction (HFpEF) by comparing them with remodeling pathways and protein pattern alterations in patients with HFrEF. In addition, the study aims to identify molecular alterations that would allow early identification of the development of PH-HFpEF and PH-HFrEF, affecting the female gender more

NCT ID: NCT05735041 Active, not recruiting - Clinical trials for Mild Cognitive Impairment

Computerized Cognitive Training in Patients With Coronary Heart Disease and Mild Cognitive Impairment

COG-T CHD
Start date: January 18, 2023
Phase: N/A
Study type: Interventional

In this study, a multicentre, double-blind, randomized controlled study based on cognitive training was conducted in patients with coronary heart disease and cognitive impairment but without dementia, to evaluate the effectiveness of computer-based digital therapy in improving the cognitive function of such patients.