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Effects of HFOT on Exercise Performance in Patients With COPD. A Randomized, Controlled Trial.

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Effects of High Flow Oxygen Therapy on Exercise Performance in Patients With Chronic Obstructive Pulmonary Disease. A Randomized, Controlled Trial.

Clinical Trial Summary

This will be a randomized, cross-over trial evaluating the efficacy of nasal high-flow oxygen therapy (HFOT) vs. low-flow oxygen therapy (LFOT) on cycling endurance in patients with chronic obstructive pulmonary disease (COPD).

Clinical Trial Description

This will be a randomized, cross-over trial evaluating the efficacy of nasal HFOT vs. LFOT on cycling endurance in patients with COPD. Each patient will perform two constant load cycling exercise tests to exhaustion using HFOT and LFOT on two consecutive days, respectively, according to randomization. The load of the cycle ergometer will be set at 75% of the individually estimated maximum work rate (Wmax). During exercise tests, LFOT will be provided by a standard nasal cannula at a flow rate of 3 L/min using an oxygen concentrator. HFOT will be applied by a dedicated large bore nasal cannula at a flow rate 60 L/min, FiO2 45%, temperature 32 °C, using a HFOT device. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03955770
Study type Interventional
Source University of Zurich
Contact
Status Completed
Phase Phase 4
Start date May 20, 2019
Completion date August 2, 2019
View Details
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