Contrast Induced Nephropathy Clinical Trial
Official title:
The Evaluation of the Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN) in Patients With Pulmonary Edema,Severe Heart Failure or Uncontrolled Hypertension
Verified date | November 2008 |
Source | Tehran University of Medical Sciences |
Contact | n/a |
Is FDA regulated | No |
Health authority | Iran: Ministry of Health |
Study type | Interventional |
Radio Contrast Induced Nephropathy (RCIN) remains a well recognized complication in patients undergoing diagnostic or interventional procedures requiring radiographic contrast agents. Recent studies have shown benefit in administering Sodium Bicarbonate over normal saline( the uniformly accepted prophylaxy) in preventing RCIN.But most studies have excluded patients with history of pulmonary edema, severe heart failure(NYHA 3-4), uncontrolled hypertension or ejection fraction less than 30%. Therefore the aim of this study is to evaluate the efficacy of sodium bicarbonate solved in half saline compared with infusion of half saline in prevention of RCIN in these groups of patients.
Status | Completed |
Enrollment | 72 |
Est. completion date | July 2008 |
Est. primary completion date | July 2008 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - individuals aged 18 years or older with serum creatinine levels of at least 1.5 mg/dl , who were scheduled to undergo diagnostic or therapeutic coronary artery angiography. - Patients with a history of Pulmonary edema or - Patients with severe Heart Failure ( NYHA 3-4) or - Patients with ejection fraction of less than 30% on Echocardiography ( done in the previous month of admission) or - Patients with uncontrolled hypertension (treated systolic blood pressure more than 160 mmHg, or diastolic blood pressure more than 100mmHg ) Exclusion Criteria: - serum creatinine levels of more than 8 mg/dl - previous history of dialysis - GFR < 20 ( as calculated with this formula: ((140-Age)(Weight(Kg)) / Serum Creatinine(mg/dl) ×72 ) , in females GFR was multiplied by 0.85 ) - emergency catheterization - recent exposure to radiographic contrast agents (within previous two days of the study) - radiocontrast agent dosage needed more than 300 gr during the procedure - allergy to radiocontrast agent - pregnancy - administration of dopamine, mannitol , fenoldopam or N-Acetyl Cystein during the intended time of study - need for continuous hydration therapy (e.g. sepsis ) - history of Multiple myeloma |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Iran, Islamic Republic of | Tehran Heart Center | Tehran |
Lead Sponsor | Collaborator |
---|---|
Tehran University of Medical Sciences | Tehran Heart Center |
Iran, Islamic Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | development of contrast induced nephropathy defined as an absolute (> or = 0.5 mg/dl) or relative increase (> or = 25%) in serum creatinine at 48 hours after exposure to a contrast agent compared to baseline serum creatinine values. | at 48 hours | Yes | |
Secondary | an absolute (> or = 0.5 mg/dl) or relative increase(> or= 25% ) in serum creatinine at day 5 after exposure to a contrast agent. | at day 5 | Yes | |
Secondary | Urine PH after initial bolus | within 6 hours after initial bolus | Yes | |
Secondary | development of contrast induced nephropathy defined as 25% decrease in glomerular filtration rate (GFR) at 48 hours. | at 48 hours | Yes | |
Secondary | development of contrast induced nephropathy defined as 25% decrease in glomerular filtration rate (GFR)on day 5 . | on day 5 post contrast | Yes |
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