A Thyroid Hormone Analog to Fight Heart Failure: Phase II Trial (DITPA)

Congestive Heart Failure Clinical Trial

Official title:

CSP #526 - A Thyroid Hormone Analog to Fight Heart Failure: Phase II Trial (DITPA)

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00032643
• Other study ID #: 526
• Status: Terminated
• Phase: Phase 2
• First received: March 27, 2002
• Last updated: November 4, 2013
• Start date: June 2004
• Est. completion date: December 2006

Study information

• Verified date: November 2013
• Source: VA Office of Research and Development
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal GovernmentUnited States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

Congestive heart failure (CHF) affects 4-5 million Americans, and its prevalence is predicted to increase over the next few decades. Thyroid hormone has unique actions which make it a novel and potentially useful agent for treatment of CHF. Due to possible adverse affects of thyroid hormone, there is interest in developing analogs with fewer undesirable side effects. 3,5- diiodothyropropionic acid (DITPA) has been shown to improve diastolic function in both animal models and a recently completed double-blind placebo controlled trial in 19 humans.

The goal of the proposed Phase II study is to show safety and demonstrate a medication of efficacy of DITPA needed in patients with CHF. This study is a prerequisite for a larger Phase III trial which would determine whether mortality is improved with DITPA. To better define the appropriate doses, prior to the Phase II study we will conduct an initial pharmacokinetic study.

Description:

Intervention: After enrollment, patients receive a clinical assessment, echocardiogram and laboratory studies. Then, each patient receives treatment with one of two doses of 3,5-diiodothyropropionic acid (DITPA) or placebo for six months.

Primary hypothesis: DITPA will improve cardiovascular function and clinical status in patients with moderately severe heart failure and be similar to placebo on safety measures.

Secondary hypothesis:

Primary Outcomes: 1. Composite endpoint composed of cardiovascular mortality/morbidity, change in NYHA class and change in global assessment, and 2. safety.

Study Abstract: Congestive heart failure (CHF) affects 4-5 million Americans, and its prevalence is predicted to increase over the next few decades. Thyroid hormone has unique actions which make it a novel and potentially useful agent for treatment of CHF. Due to possible adverse effects of thyroid hormone, there is interest in developing analogs with fewer undesirable side effects. DITPA has been shown to improve diastolic function in both animal models and a recently completed double-blind placebo controlled trial in 19 humans.

The goal of the proposed Phase II study is to define the dose of DITPA needed to achieve hemodynamic improvement in patients with CHF. This study is a prerequisite for a larger Phase III trial which would determine whether mortality is improved with DITPA. To better define the appropriate doses, prior to the Phase II study we will conduct an initial pharmacokinetic study.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 150
• Est. completion date: December 2006
• Est. primary completion date: December 2006
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

INCLUSION

To be enrolled, patients must:

1. be veterans,

2. have moderately severe CHF (NYHA class II, III or IV),

3. be 18 or older,

4. not have clinically important renal, hepatic or hematological disorders or clinically significant abnormal laboratory findings,

5. not have a pre-existing thyroid disease,

6. not have anemia (hematocrit less than 30%),

7. not have chronic pulmonary disease that limits exercise tolerance or requires use of chronic bronchodilator therapy or steroids,

8. be able to walk on the level for 6 minutes,

9. not have hemodynamically significant pericardial disease,

10. not have angina pectoris severe enough to require frequent administration of sublingual nitroglycerin,

11. not have acute myocardial infarction within 6 months of screening,

12. not have inoperable aortic stenosis,

13. not have symptomatic ventricular arrhythmias or ventricular arrhythmia requiring pharmacological therapy,

14. not have implanted cardioverter defibrillator,

15. not be taking amiodarone,

16. not have demonstrated non-compliance with prior medical regimes;

17. not be on an investigational drug,

18. not have a medical condition that, in the investigator's opinion, would make the patient ineligible,

19. not have an allergy to iodine or shellfish,

20. not be in sinus rhythm,

21. not be of childbearing potential,

22. have an ejection fraction greater than 40%.

Exclusion Criteria:

Study Design

Masking: Double-Blind

Related Conditions & MeSH terms

• Congestive Heart Failure
• Heart Failure

Intervention

Drug:
• DITPA

Locations

Country	Name	City	State
United States	Ralph H Johnson VA Medical Center, Charleston	Charleston	South Carolina
United States	VA Medical Center, Cleveland	Cleveland	Ohio
United States	VA Eastern Colorado Health Care System, Denver	Denver	Colorado
United States	VA Medical Center, Minneapolis	Minneapolis	Minnesota
United States	VA South Texas Health Care System, San Antonio	San Antonio	Texas
United States	Southern Arizona VA Health Care System	Tucson	Arizona
United States	VA Greater Los Angeles Healthcare System, West LA	West Los Angeles	California

Sponsors (1)

Lead Sponsor	Collaborator
VA Office of Research and Development

Country where clinical trial is conducted

United States,