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Clinical Trial Summary

Hypersexual Disorder (HD), sometimes called "sexual addiction", is a disorder with intense sexual desires and psychological preoccupations that lead to out-of-control sexual activities with severe consequences. HD is related to higher risks of HIV infection and an important risk factor for committing sexual crimes. The prevalence of HD is 3-6% of the general population, thus, a significant burden for society. The neurobiological mechanisms behind HD are still unknown, and there is still a great need for causal treatments.

This study is aimed at identifying neurobiological and psychological mechanisms underlying HD as a basis for treatment development. The overall goal is to improve mental health, quality of life, diagnosis and treatment options for affected individuals, and to reduce the impact HD can have on society. Patients with HD will be recruited at Karolinska University Hospital in close collaboration between endocrinologists, psychologists, psychiatrists, and brain researchers at Karolinska Institutet. Cases and healthy controls will undergo brain scans (MRI), psychological and blood tests to quantify neurobiological, cognitive, and behavioral aspects of HD.

This study is directly integrated into clinical practice, can identify important targets for interventions and factors predicting treatment outcomes. This study is essential for a better understanding of HD, the improvement of treatments, and can have significant impact on the prevention of HIV infections and sexual crimes.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT03495414
Study type Observational
Source Karolinska Institutet
Contact Christoph Abé, PhD
Phone +46 8-524 832 60
Status Recruiting
Start date April 1, 2018
Completion date December 30, 2020

See also
  Status Clinical Trial Phase
Completed NCT00467558 - Double-Blind Naltrexone in Compulsive Sexual Behavior Phase 2
Completed NCT02300051 - Intervention Study for Individuals With Compulsive Sexual Behavior N/A