Colorectal Cancer Clinical Trial
Official title:
Study of Diagnostic Tests Studying Kinetic Variation of Serum Matrix Metalloproteases After Surgical Treatment and/or Destruction by Radiofrequency in Patients With Hepatic Metastases From Colorectal Cancer
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research trial is studying matrix metalloproteinases after surgery or
radiofrequency ablation in patients with liver metastases from colorectal cancer.
OBJECTIVES:
Primary
- Describe the kinetics of postoperative changes of serum matrix metalloproteinases (MMP)
(MMP-1, MMP-2, MMP-7, MMP-9) and their inhibitors (TIMP) (TIMP-1, TIMP-2) as a function
of surgical technique.
Secondary
- Determine the predictive value of postoperative risk of recurrence.
- Correlate the risk of recurrence with surgical technique.
- Determine whether elevated serum levels of MMP are a better marker than the
carcinoembryonic antigen of hepatic or extrahepatic recurrence.
- Determine whether the postoperative serum of HGF/SF is correlated to changes in plasma
levels of MMPs.
OUTLINE: Blood samples are collected periodically before and after treatment to analyze for
metalloproteinases and their inhibitors.
After completion of study treatment, patients are followed at day 45 and then every 3 months
for 2 years.
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