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Clinical Trial Summary

CO40939 is a Phase Ib, open-label, multicenter, single-arm study designed to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of cibisatamab in combination with atezolizumab administered after pretreatment with obinutuzumab in patients with Stage IV microsatellite stable (MSS) metastatic colorectal cancer (mCRC) whose tumors have high carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and who have progressed on two or more chemotherapy regimens. The study is composed of a safety run-in and an exploratory part.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT03866239
Study type Interventional
Source Hoffmann-La Roche
Contact Reference Study ID Number: CO40939 www.roche.com/about_roche/roc
Phone 888-662-6728 (U.S. and Canada)
Email global-roche-genentech-trials@gene.com
Status Recruiting
Phase Phase 1
Start date May 2, 2019
Completion date February 11, 2022

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