Microbiota-anastomotic Leak Among Colorectal Surgery Patients : Pilot Study

Colorectal Cancer Clinical Trial

Official title: The Relationship Between Intestinal Microbiota, Colorectal Cancer and Anastomotic Leakage After Colorectal Surgery: Pilot Study

Status Completed

Clinical Trial Summary

The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a different preoperative microbiota than healthy patients. This different composition is probably induced by the high heme level in the light intestinal tract that tumor spoliation generates.

The objective of the study is to evaluate the feasibility of a larger study to evaluate the difference between microbiota composition of patients with and without colorectal cancer, with inflammatory bowel disease and those with and without anastomotic leakage postoperatively of a colonic resection.

Stool samples will be taken from 20 patients, including 5 without intestinal pathology, 5 with colorectal cancer undergoing colorectal surgery, 5 with inflammatory bowel disease and 5 with anastomotic leakage after colectomy for colorectal cancer or inflammatory bowel disease.

The stool samples will be analyzed at CRCHUM to draw up a profile of the bacteria that make up the microbiota of each patient.

Clinical Trial Description

No more details required. ;

Related Conditions & MeSH terms

• Anastomotic Leak
• Colorectal Cancer
• Colorectal Neoplasms
• Inflammatory Bowel Diseases
• Microbiota

• NCT number: NCT03496441
• Study type: Observational
• Source: Centre hospitalier de l'Université de Montréal (CHUM)
• Status: Completed
• Start date: January 30, 2018
• Completion date: April 1, 2018