Colorectal Cancer Clinical Trial
Official title:
Investigation of the Clinical and Laboratory Efficacy of Autogemotherapy Based on Autologous Antigen-activated Dendritic Cells in the Treatment of Patients With Colorectal Cancer
The purpose of this work: to assess the tolerability and effectiveness of the autogemotherapy
method on the basis of autologous antigen-activated dendritic cells in the treatment of
patients with colorectal cancer.
This technology is intended for complex treatment of patients with colorectal cancer and is
aimed at preventing the occurrence and treatment of secondary foci. The need for this
technology is justified by the widespread occurrence of colorectal cancer, a decrease in the
average age at onset of the disease, and the chemoresistantness of locally advanced forms of
cancer.
Currently, technologies are being developed to improve the clinical outcomes of patients with complex treatment of colorectal cancer. Many patients are immunosuppressed after surgical, radiation and chemotherapeutic treatment, which leads to dysfunction of T cells, resulting in tumor cells avoiding immune surveillance. Restoration of antitumor immunity during immunotherapy is one of the modern approaches in the treatment of colorectal cancer, which contributes to the formation of an effective specific immune response, the destruction of tumor cells while minimizing toxicity. Dendritic cells (DC) and the lymphocytes induced by them are one of the most effective methods for the destruction of residual cancer cells, which are the leading cause of relapse and metastasis. ;
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