Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib

Status Terminated

Clinical Trial Summary

This is a Phase 1 open-label, dose-escalation trial using "3+3" design, evaluating MM-151 co-administration with MM-121, MM-141, and trametinib at varying dose levels.

Clinical Trial Description

This is a two-part Phase 1, non-randomized, open-label study of MM-151 plus MM-121, MM-141, or trametinib in patients with advanced, heregulin-positive lung, head and neck, and colorectal cancers. In part 1 of the study, cohorts of 3 or more patients will be treated at escalating doses of MM-151 in combination with MM-121, MM-141, and trametinib until a maximum tolerated combination dose for each combination is identified. In part 2 of the study, patients will be treated with the combination dose identified in part 1 of the study. ;

Study Design

Related Conditions & MeSH terms

Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Colorectal Cancer
Colorectal Neoplasms
Head and Neck Neoplasms
Non-small Cell Lung Cancer
Squamous Cell Carcinoma of the Head and Neck

Clinical Trial Details

NCT number	NCT02538627
Study type	Interventional
Source	Merrimack Pharmaceuticals
Contact
Status	Terminated
Phase	Phase 1
Start date	August 2015
Completion date	October 5, 2016

View Details

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