Interactions Between Intravenous (IV) Cocaine and Lofexidine

Cocaine Related Disorders Clinical Trial

Official title:
Phase 1, Double-Blind, Placebo-Controlled Assessment of Potential Interactions Between Intravenous Cocaine and Lofexidine

Status Terminated

Clinical Trial Summary

The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and treatment with lofexidine.

Clinical Trial Description

To determine the safety of daily oral lofexidine alone and concurrent with IV cocaine infusions of 20 mg and 40 mg in cocaine-experienced, non-opiate-addicted volunteers. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01148992
Study type	Interventional
Source	National Institute on Drug Abuse (NIDA)
Contact
Status	Terminated
Phase	Phase 1
Start date	August 2010
Completion date	March 2011

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00535002` - The Effect of Yohimbine on Cocaine Cue Reactivity	N/A
Completed	`NCT01815645` - Contingency Management Treatment for Crack Addiction - Study With Brazilian Population	N/A
Completed	`NCT00613015` - Stress and Medication Effects on Cocaine Cue Reactivity	Phase 2
Completed	`NCT01392092` - Effects of N-acetylcysteine on Brain Chemistry and Behavior in Cocaine Abusers (NAC)
Completed	`NCT00946660` - Non-Treatment Study of Factors Affecting Cocaine Drug Choice	N/A
Completed	`NCT00495092` - Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients	Phase 2/Phase 3
Completed	`NCT01189578` - Brain Imaging of Cocaine Craving in Recreational Cocaine Users	N/A