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Cocaine-Related Disorders clinical trials

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NCT ID: NCT02935101 Terminated - Cocaine Dependence Clinical Trials

Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants

Goliath
Start date: October 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate whether prednisolone lowers intensity and frequency of craving in heroin-addicted subjects undertaking a detoxification of cocaine and/or heroin.

NCT ID: NCT01535937 Terminated - Cocaine Dependence Clinical Trials

The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence

Start date: February 2012
Phase: Phase 1/Phase 2
Study type: Interventional

This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse prevention (MBRP) therapy, using a 5 week combined laboratory-inpatient and outpatient double-blind, randomized, controlled trial.

NCT ID: NCT01431586 Terminated - Cocaine Dependence Clinical Trials

First in Humans Study of JDTic

Start date: n/a
Phase: Phase 1
Study type: Interventional

This is the first study to be conducted in humans for JDTic, a new chemical entity, with evaluations focusing on the safety, tolerability, and pharmacokinetics (PK) of JDTic following administration of single oral doses. JDTic is a novel, selective κ opioid receptor antagonist and is currently being developed by RTI International as a potential pharmacotherapy to treat cocaine dependence. This study has the possibility of identifying the maximum tolerated dose in humans and a surrogate measure of JDTic pharmacodynamic (PD) activity. Data from this study will be used to plan for and define dose ranges for subsequent studies, as well as to identify potential indicators of JDTic pharmacological activity.

NCT ID: NCT01148992 Terminated - Clinical trials for Cocaine Related Disorders

Interactions Between Intravenous (IV) Cocaine and Lofexidine

Start date: August 2010
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and treatment with lofexidine.

NCT ID: NCT00951314 Terminated - Cocaine Dependence Clinical Trials

Brain Glutamate Receptors and Cocaine Dependence

Start date: July 14, 2009
Phase: N/A
Study type: Observational

Objective: Cocaine addiction continues to be an important public health problem with over 1.7 million users in the US alone. Cocaine addiction is characterized by compulsive drug use despite adverse consequences and high rates of relapse during periods of abstinence. Cocaine addiction may be mediated by neuroadaptations in reward-related learning and memory processes in the mesocorticolimbic dopamine system and glutamatergic corticolimbic circuitry. Metabotropic glutamate subtype 5 receptors (mGluR5) likely play essential roles in mediating some of the actions of drugs of abuse. Animal studies have shown that mGluR5 knock-out or blockade reduces self-administration of cocaine and cocaine-induced hyper-locomotion. However, to what extent mGluR5 are involved in the pathophysiology of cocaine addiction in humans is currently unknown, partly due to the lack of suitable methods to reliably quantify mGluR5 in the living human brain. This protocol aims to determine whether the density of mGluR5 in brain is altered in participants with cocaine addiction compared to healthy controls using positron emission tomography (PET) and the recently developed radiotracer for mGluR5, [18F]SP203. We also aim to determine whether this density is related to genotype, history of cocaine use, and/or craving for cocaine. Study Population: The study populations will consist of healthy adults with no history of substance abuse and a matched group of healthy current primary cocaine dependent male and female participants (20-50 years old.; N=40/group). Design: Density of mGluR5 will be measured in cocaine dependent participants and healthy adults volunteers with PET and (18F)SP203, a radioligand with specificity for mGluR5. All participants will undergo genotyping to identify normal or variant mGluR5 gene associated with drug abuse. The intensity of craving for cocaine will be assessed while watching a video about cocaine use. Outcome measures: Density of mGluR5 will be compared between cocaine dependent participants and healthy controls. In addition, correlation among the genetic polymorphism, the craving response, and the density of mGluR5 will be determined.

NCT ID: NCT00729300 Terminated - Cocaine Addiction Clinical Trials

A Study of the Relationship Between Disulfiram and Cocaine Self-administration.

Start date: April 2006
Phase: Phase 1/Phase 2
Study type: Interventional

The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence. A common assumption has been that disulfiram treatment, by increasing DA availability, enhances the aversive aspects of stimulants. This study aims to measure plasma activity in those with the C/C DBH genotype, which is associated with higher DBH activity subsequently making the disulfiram treatment more effective, as well as determine the effects of treatment with disulfiram on cocaine self-administration using a human laboratory model of cocaine self-administration.

NCT ID: NCT00688805 Terminated - Cocaine Dependence Clinical Trials

Effects of Propranolol on Responses to Drug-Related Imagery Scripts

Start date: December 12, 2007
Phase: Phase 1
Study type: Interventional

Background: - Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of responses such as rapid heartbeat and desire for cocaine. This type of memory is reconsolidated (actively re-stored) each time it is reactivated; however, the reconsolidation process can be disrupted by the drug propranolol, which weakens the link between that memory and an emotional response. - Propranolol is traditionally used to treat high blood pressure and other heart-related conditions. Researchers are interested in studying whether propranolol disrupts reconsolidation of drug-cued memories in individuals who are addicted to cocaine. Objectives: - To examine whether propranolol can interfere with reconsolidation of cocaine-related memories and reduce cravings and drug use in substance abusers. Eligibility: - Individuals between 18 and 55 years of age who are current cocaine users enrolled in a methadone treatment program. Design: - The study will involve four long sessions (visits 1, 4, 6, and 14) and 10 short sessions. The short visits will be for monitoring of participants use of drugs and alcohol; the longer visits will involve more tests and lab sessions. Participants will be randomized to either the propranolol or placebo group. - The long sessions will involve the following procedures: - An interview session to develop a personalized drug script/cue set. - A two-hour intervention session with baseline measures, drug administration (propranolol or placebo), and two script-guided imagery sets. This is the only administration of propranolol during the study. - Two follow-up test sessions, 1 and 5 weeks after the intervention session. - Participants will make brief visits to our outpatient clinic for twice-weekly monitoring of ongoing drug use via urine screens and self-report, starting 1 week before the intervention session and ending 5 weeks later.

NCT ID: NCT00514202 Terminated - Clinical trials for Substance-Related Disorders

Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-deficit Hyperactivity Disorder (ADHD)

Start date: August 2007
Phase: Phase 2
Study type: Interventional

Dextroamphetamine is commonly used to treat ADHD, and recent evidence suggests that this medication may decrease drug use in individuals dependent on cocaine. Thus, the present pilot study will determine the ability of dextroamphetamine to treat individuals with both cocaine dependence and ADHD.

NCT ID: NCT00373581 Terminated - Cocaine Dependence Clinical Trials

Effects of Vigabatrin on Cocaine Self-Administration

Start date: April 2006
Phase: Phase 2
Study type: Interventional

The objective of this study is to determine if vigabatrin will decrease cocaine self-administration, cardiovascular effects, subjective effects and craving compared to placebo.

NCT ID: NCT00240227 Terminated - Alcoholism Clinical Trials

Prazosin for ETOH or Cocaine Craving

Start date: April 2004
Phase: N/A
Study type: Interventional

This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-dependent and alcohol-dependent veterans. Both the study medication period and the placebo period are each 4 weeks in duration.