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Cocaine-Related Disorders clinical trials

View clinical trials related to Cocaine-Related Disorders.

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NCT ID: NCT03471182 Recruiting - Cocaine Dependence Clinical Trials

Investigation of Cocaine Addiction Using mGluR5 PET and fMRI

Start date: February 26, 2018
Phase: Phase 1
Study type: Interventional

The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts. Currently-using and non-treatment-seeking individuals with a cocaine use disorder will undergo a cocaine self-administration paradigm 2-5 days prior to completing positron emission tomography (PET) and functional magnetic resonance imaging (fMRI).

NCT ID: NCT03349606 Recruiting - Cocaine Dependence Clinical Trials

Cocaine Use Disorder and Cortical Dopamine

Start date: June 2, 2010
Phase: Early Phase 1
Study type: Interventional

The goal of this study is to use [C-11]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls

NCT ID: NCT03345394 Recruiting - Clinical trials for Substance Use Disorders

Effectiveness of Contingency Management in the Treatment of Crack Addiction in Brazil

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

Crack addiction has become a severe public health problem in Brazil. Crack users present elevated prevalence rates of psychiatric comorbidities, sexual transmitted infections and unemployment with high probability of living or have lived in the streets, history of incarceration and engagement in illegal activities. For the last 20 years a treatment called Contingency Management (CM) have achieved the best results regarding reduction of substance use, promotion of abstinence, treatment attendance and retention in treatment. The first CM study conducted in Brazil advocates for the efficacy of CM on all of these outcomes, suggesting that CM can be effective in a Brazilian population of crack users.

NCT ID: NCT03333460 Recruiting - Cocaine Dependence Clinical Trials

Transcranial Magnetic Stimulation for Cocaine Addiction

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed. Repetitive transcranial magnetic stimulation (rTMS) stimulates non-invasively parts of the brain. Preliminary data suggest that rTMS may help reducing cocaine craving and consumption. Researchers want to learn how the brain and the drug-seeking behavior may change with this treatment. Objectives: To test if rTMS can reduce cocaine craving and use, and also affect several mood, behavioral and cognitive alterations associated with prolonged cocaine use. Eligibility: Healthy, right-handed adults ages 18-65 who do have cocaine use disorder (moderate to severe). Design: This is a randomized, double-blind, sham-controlled study. The study includes three phases: 1) a rTMS continued treatment phase; a rTMS follow-up; and a no rTMS follow-up. Prior to participating, participants will be screened with: - Questionnaires - Medical history - Physical exam - Urine tests - MRI (structural) After being enrolled, baseline behavioral and imaging data will be collected. In particular, participants will undergo: - Questionnaires - Functional MRI During the continued rTMS phase, participants with cocaine use disorder will be randomized to receive real or fake rTMS. Repetitive TMS will be delivered during 10 outpatient treatment days, over 2 weeks (5 days/week). Following this phase, subjects will have 12 follow-up visits (once/weekly), during which they will receive rTMS, and behavioral and imaging assessments will be performed. At the end of the rTMS follow up period, participants will further receive 3 follow up visits (once a month), during which rTMS will not be performed, but behavioral data will be collected. Treatment includes: - rTMS: A coil is placed on the head. A brief electrical current passes through the coil. At each visit, participants will receive two rTMS sessions, with a 1hr interval between sessions. At the beginning of each rTMS session, they view cocaine-related images for few minutes. - MRIs at baseline and at follow-up visit #12: Participants lie on a table that slides into a cylinder that takes pictures of the brain. They respond to images while in the scanner. - Repeat of screening tests and questionnaires - Urine toxicological screen

NCT ID: NCT03242928 Recruiting - Clinical trials for Cocaine-related Disorder

Study to Investigate Whether AFQ056 Reduces Cocaine Use in Patients Diagnosed With Cocaine Use Disorder (CUD)

Start date: December 4, 2017
Phase: Phase 2
Study type: Interventional

This will assess whether AFQ056 can have a beneficial effect by reducing cocaine use in Cocaine Use Disorder (CUD) patients as assessed by Timeline Follow-Back cocaine self-report.

NCT ID: NCT03238859 Recruiting - Alcohol Dependence Clinical Trials

10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence

Start date: August 1, 2016
Phase: Phase 2
Study type: Interventional

The goal of this double-blind sham controlled study is to evaluate the effeicacy of continuous theta burst stimulation to the frontal pole as a tool to decrease drug cue reactivity and improve treatment outcomes in treatment-engaged cocaine and alcohol users. All participants will be randomized to receive 10 days of real or sham rTMS to the frontal pole. Brain imaging data and behavioral assessments will be collected at 4 time points - before TMS, after 10 days of TMS, 1 month follow up and 2 month follow up.

NCT ID: NCT03143543 Recruiting - Clinical trials for Opioid-Related Disorders

Phase I Functional Magnetic Resonance Imaging (fMRI) Pharmacodynamic Studies of Compounds for Opioid Use Disorder and Cocaine Use Disorder

Start date: July 2015
Phase: Phase 1
Study type: Interventional

The purpose of Project 2 is to execute phase I functional magnetic resonance imaging (fMRI) studies to assess the effects of lorcaserin on brain target engagement (measured by fMRI brain activation and neural connectivity) in cocaine use disorder (CocUD) subjects and/or opioid use disorder.

NCT ID: NCT03018236 Recruiting - Cocaine Addiction Clinical Trials

Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.

Start date: January 2017
Phase: Phase 4
Study type: Interventional

This study evaluates the use of N-acetylcysteine in the treatment of alcohol and cocaine use disorders. Alcohol users will be split in two groups, one will receive the active N-acetylcysteine and the other placebo. The same division will occur with cocaine users. The effects of N-acetylcysteine in adherence, abstinence, psychiatric symptoms and stress biomarkers will be evaluated.

NCT ID: NCT03007394 Recruiting - Clinical trials for Cocaine-Related Disorders

Lorcaserin in the Treatment of Cocaine Use Disorder

Start date: June 19, 2017
Phase: Phase 2
Study type: Interventional

The objective of this study is to evaluate the efficacy and safety of lorcaserin in the treatment of cocaine use disorder.

NCT ID: NCT02994875 Recruiting - Cocaine Dependence Clinical Trials

Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence

Start date: May 2016
Phase: Early Phase 1
Study type: Interventional

The objective of this research is to identify the functional neural mechanisms (as assessed using fMRI) of short-term N-acetylcysteine (NAC) administration among methadone-maintained individuals with cocaine dependence.