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Cocaine-Related Disorders clinical trials

View clinical trials related to Cocaine-Related Disorders.

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NCT ID: NCT02939352 Completed - Alcoholism Clinical Trials

The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues

Start date: September 2014
Phase: Phase 1
Study type: Interventional

High relapse rates among substance dependent individuals are likely due to a combination of factors that involve limbic circuits in the brain involved in craving, including vulnerability to salient cues. Emerging data suggests that non-invasive, targeted brain stimulation may be able to modulate activity in these circuits and decrease craving. The primary goal of this pilot study is to determine the extent to which a single session of continuous theta burst stimulation (TBS) to the medial prefrontal cortex can attenuate limbic circuitry involved in craving among cocaine users and alcohol users. This will be tested through a double-blind,sham-controlled brain stimulation and brain imaging study in a cohort of polysubstance abusers and alcohol users.

NCT ID: NCT02797990 Completed - Pregnancy Clinical Trials

Conflict Between Maternal Autonomy and Child Health in Substance-use

Start date: May 2016
Phase: N/A
Study type: Observational

Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.

NCT ID: NCT02774343 Completed - Clinical trials for Alcohol Use Disorder

PPARĪ³ Agonist Treatment for Cocaine Dependence

Start date: August 2012
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine use and reduce cocaine craving and drug use in cocaine dependent patients.

NCT ID: NCT02768441 Completed - Cocaine Addiction Clinical Trials

Dexamphetamine Sustained Release Pharmacokinetics and Clinical Validation of Dried Blood Spots

Start date: November 1, 2016
Phase: Early Phase 1
Study type: Interventional

The pharmacokinetics of 10 to 12 individuals receiving 60 mg of sustained release dexamphetamine will be studied. These individuals have received this medication before in a previous trial where the pharmacodynamics were investigated. This trial will last 5 consecutive days during which blood samples will be drawn for pharmacokinetics analyses. Dried blood spots will also be collected for the clinical validation of the bioanalytical method wherein these are used.

NCT ID: NCT02626494 Completed - Cocaine Addiction Clinical Trials

Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction

Start date: March 2015
Phase: Phase 4
Study type: Interventional

This study aims at testing for the impact of glutamatergic changes on drug craving in cocaine addiction, and to evaluate the effects of n-acetylcysteine (n-AC) on both glutamate homeostasis and craving using a randomized, double-blind, placebo controlled cross-over design.

NCT ID: NCT02596022 Completed - Cocaine Dependence Clinical Trials

The Effect of Glutamatergic Modulation on Cocaine Self-administration

Start date: June 2013
Phase: Phase 2
Study type: Interventional

Repeated drug consumption may progress to problematic use by triggering neuroplastic adaptations that attenuate sensitivity to natural rewards while increasing reactivity to craving and drug cues. Converging evidence suggests that glutamate modulation may work to correct these adaptations and rapidly restore motivation for delayed non-drug rewards relative to immediate drug use. Using an established laboratory model aimed at evaluating behavioral shifts in the salience of cocaine now vs. money later, the investigators will test the effect of CI-581a on cocaine self-administration as compared to the active control.

NCT ID: NCT02393599 Completed - Cocaine Abuse Clinical Trials

Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin

Start date: May 2015
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to determine if there are significant interactions between oral lorcaserin treatment concurrent with 20 and 40 mg intravenous (i.v.) cocaine infusions by measuring adverse events (AEs) and cardiovascular responses including heart rate (HR), blood pressure (BP), and electrocardiogram (ECG) (including QTc).

NCT ID: NCT02080832 Completed - Cocaine Dependence Clinical Trials

Brain Function and Structure in Cocaine Dependence

Start date: February 2010
Phase: Phase 2
Study type: Interventional

The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.

NCT ID: NCT02080819 Completed - Cocaine Dependence Clinical Trials

Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse

Start date: February 2014
Phase: Phase 2
Study type: Interventional

This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.

NCT ID: NCT01984177 Completed - Clinical trials for Substance-Related Disorders

Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence

Start date: June 2013
Phase: N/A
Study type: Observational

This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups. Dopamine release will be measured using PET neuroimaging with the radiotracer [11C]-(+)-PHNO.