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Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

Cocaine Dependence Clinical Trial

Official title:
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET

Clinical Trial Summary

This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to healthy control (HC) subjects using 11C-UCB-J PET. Subjects will undergo a single 11C-UCB-J (also known as 11C-APP311) PET scan. This would be the very first to image synaptic density in human cocaine and opiate users, thereby testing whether altered synaptic density in the rodent brain is recapitulated in CUD and OUD humans. If confirmed, the current study would provide compelling clinical-translational support for an important pathophysiological mechanism of addiction - aberrant structural synaptic plasticity. As such, the current study has considerable potential for advancing the neurobiological understanding of human cocaine and opiate addiction.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03527485
Study type Interventional
Source Yale University
Contact
Status Completed
Phase N/A
Start date January 1, 2019
Completion date March 28, 2023
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