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Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence

Cocaine Dependence Clinical Trial

Official title:
Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence

Clinical Trial Summary

The objective of this research is to identify the functional neural mechanisms (as assessed using fMRI) of short-term N-acetylcysteine (NAC) administration among methadone-maintained individuals with cocaine dependence.

Clinical Trial Description

The objective of this research is to identify the functional neural mechanisms (as assessed using fMRI) of short-term N-acetylcysteine (NAC) administration among methadone-maintained individuals with cocaine dependence. Specifically, this application proposes to conduct a randomized, double-blind, placebo-controlled, cross-over pilot study to examine the effects of 7-day NAC administration (2400mg/day) on the neural networks engaged during response inhibition (Go/No-Go task) and affective (emotion-regulation task) processes among cocaine-dependent, methadone-maintained individuals (n=40; 20 per treatment-order condition). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02994875
Study type Interventional
Source Yale University
Contact
Status Completed
Phase Early Phase 1
Start date May 2016
Completion date September 2020
View Details
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