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NCT number NCT03349606
Study type Interventional
Source University of Pittsburgh
Contact Rajesh Narendran, MD
Email narendranr@upmc.edu
Status Recruiting
Phase Early Phase 1
Start date June 2, 2010
Completion date December 31, 2020

Clinical Trial Summary

The goal of this study is to use [C-11]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls


Clinical Trial Description

This study seeks to examine dopamine (DA) transmission in vivo, using positron emission tomography (PET) with [C-11]FLB 457, in cortical regions of interest in subjects who have a history of cocaine dependence. We hypothesize that cocaine dependence is associated with decreases in dopamine in the prefrontal cortical regions compared to controls. This may explain the impulsivity and cognitive deficits that underlie relapse in this disorder.


Study Design


Related Conditions & MeSH terms


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