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Cocaine Addiction clinical trials

View clinical trials related to Cocaine Addiction.

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NCT ID: NCT04336293 Completed - Cocaine Addiction Clinical Trials

sTMS for Substance Use-disordered Veterans

Start date: September 7, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if synchronized transcranial magnetic stimulation is safe and tolerable in individuals with cocaine, opioid, or alcohol use disorders.

NCT ID: NCT03025321 Completed - Cocaine Addiction Clinical Trials

Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder

Start date: February 6, 2017
Phase: N/A
Study type: Interventional

Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction. However, little is known about the relapse rates in cocaine addiction after tDCS, despite the need for neurobiological treatments to reduce the high relapse rates in this population. The current study explores the effects of repetitive tDCS in a larger sample (N=60) of cocaine addicted patients on number of relapse days after three months. We expect that a decrease in relapse risk after tDCS is associated with cognitive control functioning. Therefore, risky decision making and inhibitory control will be measured before and after the interventions, and at three months follow-up. Ecological momentary assessment (EMA) will be used as a reliable measure for relapse, craving and mood.

NCT ID: NCT02939352 Completed - Alcoholism Clinical Trials

The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues

addictionTBS
Start date: September 2014
Phase: Early Phase 1
Study type: Interventional

High relapse rates among substance dependent individuals are likely due to a combination of factors that involve limbic circuits in the brain involved in craving, including vulnerability to salient cues. Emerging data suggests that non-invasive, targeted brain stimulation may be able to modulate activity in these circuits and decrease craving. The primary goal of this pilot study is to determine the extent to which a single session of continuous theta burst stimulation to the medial prefrontal cortex can attenuate limbic circuitry involved in craving among cocaine users and alcohol users. This will be tested through a double-blind,sham-controlled brain stimulation and brain imaging study in a cohort of polysubstance abusers and alcohol users.

NCT ID: NCT02768441 Completed - Cocaine Addiction Clinical Trials

Dexamphetamine Sustained Release Pharmacokinetics and Clinical Validation of Dried Blood Spots

Start date: November 1, 2016
Phase: Early Phase 1
Study type: Interventional

The pharmacokinetics of 10 to 12 individuals receiving 60 mg of sustained release dexamphetamine will be studied. These individuals have received this medication before in a previous trial where the pharmacodynamics were investigated. This trial will last 5 consecutive days during which blood samples will be drawn for pharmacokinetics analyses. Dried blood spots will also be collected for the clinical validation of the bioanalytical method wherein these are used.

NCT ID: NCT02626494 Completed - Cocaine Addiction Clinical Trials

Neurobiological Adaptations and Pharmacological Interventions in Cocaine Addiction

CoGlu
Start date: March 2015
Phase: Phase 4
Study type: Interventional

This study aims at testing for the impact of glutamatergic changes on drug craving in cocaine addiction, and to evaluate the effects of n-acetylcysteine (n-AC) on both glutamate homeostasis and craving using a randomized, double-blind, placebo controlled cross-over design.

NCT ID: NCT02563769 Completed - Cocaine Dependence Clinical Trials

Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study

Start date: October 24, 2016
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to determine if it is safe to use the study drug, clavulanic acid, in combination with cocaine. In this study, subjects will receive intravenous (i.v.) cocaine and the study drug, clavulanic acid. The safety of clavulanic acid is being studied so future studies can be done to find out if this drug is helpful in treating cocaine dependence. Currently, there is no available medication treatment for cocaine dependence.

NCT ID: NCT01984177 Completed - Clinical trials for Substance-Related Disorders

Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence

Start date: June 2013
Phase: N/A
Study type: Observational

This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups. Dopamine release will be measured using PET neuroimaging with the radiotracer [11C]-(+)-PHNO.

NCT ID: NCT01929343 Completed - Cocaine Addiction Clinical Trials

Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

LIDO
Start date: January 2014
Phase: Phase 2
Study type: Interventional

We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue memories. This will lead to a reduction in cue-induced craving upon repeated testing as well as subsequent cocaine use and basal craving.

NCT ID: NCT01887366 Completed - Cocaine Addiction Clinical Trials

Efficacy and Safety of TV-1380 as Treatment for Facilitation of Abstinence in Cocaine-Dependent Subjects

Start date: June 2013
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to assess the efficacy and safety of TV-1380 [Recombinant human serum albumin (HSA) mutated butyrylcholinesterase (AlbuBChE)] in facilitating abstinence in cocaine-dependent subjects.

NCT ID: NCT01822587 Completed - Cocaine Addiction Clinical Trials

Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving

Start date: September 2013
Phase: Phase 2
Study type: Interventional

The investigators' recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other drug cue-elicited responses in cocaine addicted persons. The investigators will attempt to augment this effect by a) doubling the number of propranolol-medicated cocaine cue exposure (CCE) retrieval sessions and b) increasing the dose of propranolol. It is expected that propranolol treated groups, relative to placebo treated groups, will evidence greater reduction of craving, cue reactivity and cocaine use during follow-up cocaine cue exposures. Also, these effects will be greater for those who receive 80mg of propranolol as opposed to 40mg.