Clinical Trials Logo

Clinical Trial Summary

Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes.


Clinical Trial Description

This is a prospective, multicenter, single-blind, parallel-group, adaptive randomized controlled trial (RCT) with intention-to-treat analysis which aims to determine the effects of PEEP setting guided by EIT on the clinical outcomes for moderate or severe ARDS patients ventilated with lung protective ventilation strategy. Adult patients with moderate to severe ARDS less than 72 hours after diagnosis will be included in this study. Patients in the intervention group will receive PEEP titrated by EIT with a stepwise decrease PEEP trial, whereas patients in the control group will select PEEP based on the FiO2-PEEP table. Other ventilator parameters will be set according to the ARDSnet strategy. The primary outcome is 28-day mortality. The secondary outcomes include ventilator-free days and shock-free days at day 28, length of ICU and hospital stay, the rate of successful weaning, proportion requiring rescue therapies, compilations, respiratory variables, and Sequential Organ Failure Assessment (SOFA). This study will also perform the interim analysis and subgroup analysis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05207202
Study type Interventional
Source Southeast University, China
Contact ling liu, phD
Phone 86-25-83272201
Email liulingdoctor@126.com
Status Recruiting
Phase N/A
Start date February 20, 2022
Completion date December 30, 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04516395 - Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae N/A
Recruiting NCT06219083 - Nutrition and Cancer Outcomes in Shaanxi Chemoradiotherapy
Completed NCT03354195 - MAKO-Uni-Knee Arthroplasty Clinical Outcomes and Function N/A
Active, not recruiting NCT03308929 - Prospective G7 Dual Mobility Total Hip PMCF
Not yet recruiting NCT05246722 - Registry Study of Pharmacotherapy and Clinical Outcomes in Elderly Patients With Coronary Heart Disease (PHARM-ageing)
Completed NCT03703752 - CT and Clinical Features of Internal Hernia
Recruiting NCT04326504 - Dolutegravir and Clinical Outcomes Among ART-recipients in Brazil
Not yet recruiting NCT01674816 - Minimally Invasive Three-dimensional Knee Kinematic Assessment and Surgical Guidance Using Ultrasonic Rigid Registration N/A
Not yet recruiting NCT04463134 - An Observational Study on Patients With NTM Pulmonary Disease
Completed NCT05303831 - Pattern of Disease and Determinants of Clinical Outcomes Among ICU Patients
Completed NCT06111391 - Patient Satisfaction , Prosthetic Complications and Clinical Outcomes of PEEK Composite Versus Titanium Zirconium N/A
Completed NCT03115931 - The Effect of Preoperative Nutritional Assessment and Nutritional Support on Clinical Outcomes