Chronic Tinnitus Clinical Trial
Official title:
Influence of Treatment Duration and Stimulation Frequency on Repetitive Transcranial Magnetic Stimulation in Chronic Tinnitus
Patients receive two weeks of treatment (prefrontal high-frequency and bilateral low-frequency rTMS vs. prefrontal high-frequency and bilateral high-frequency rTMS). After two weeks of treatment they can decide if they want to quit the treatment or if they want to proceed with the treatment for another two weeks.
Tinnitus is the phantom auditory perception of sound in the absence of an external or
internal acoustic stimulus. It is a frequent problem which can interfere significantly with
the ability to lead a normal life. Tinnitus has been shown to be generated in the brain, as a
result of functional reorganization of auditory and non-auditory neural pathways.
Low-frequency repetitive transcranial magnetic stimulation (rTMS) applied to the
temporoparietal areas has been investigated for the treatment of tinnitus based on the
rationale to reduce increased activity of the auditory system. Furthermore, high-frequency
stimulation of the left frontal cortex was added to this standard treatment based on rTMS
studies in affective disorders and the association of tinnitus distress with depressivity.
Thus, high-frequency stimulation of the left prefrontal cortex and low-frequency stimulation
of bilateral temporoparietal cortex was introduced as new treatment scheme in chronic
tinnitus (multisite standard).
Additionally, there is also evidence that high-frequency stimulation of the temporoparietal
cortex is effective in chronic tinnitus. Furthermore, standard treatment in chronic tinnitus
is two weeks (ten treatment days) which is shorter than the standard in rTMS in affective
disorders. Thus, the aim of the present trial is to investigate the influence of
high-frequency stimulation of the temporoparietal cortex and of increasing the number of
treatment days.
Patients receive two weeks of treatment (prefrontal high-frequency and bilateral
low-frequency rTMS vs. prefrontal high-frequency and bilateral high-frequency rTMS). After
two weeks of treatment they can decide if they want to quit the treatment or if they want to
proceed with the treatment for another two weeks.
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