Chronic Renal Failure Clinical Trial
Official title:
Evaluation of β2 Genetic Polymorphisms and the Effect of Albuterol Inhalation on Potassium and Glucose Plasma Concentration
Several studies have indicated that albuterol administered either intravenously or by
inhalation can significantly reduce plasma potassium concentration in patients suffering
from chronic renal failure.In conjunction with the decrease in potassium concentration a
modest rise in glucose concentration is usually noted. These metabolic effects are
characterized by rapid onset occurring as early as 3-5 minutes following salbutamol
administration and lasting for at least 1 hour.
The role played by ß2AR polymorphisms in determining the bronchial and vascular response to
ß2AR agonist drugs, have been confirmed by several studies.
The purpose of the present study is to examine possible causal relationships between
genetically based alteration in the structure of ß2AR and the metabolic effects of inhaled
albuterol.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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