Chronic Refractory Urticaria Clinical Trial
Official title:
A Randomised Study to Assess and Compare the Efficacy of Cyclosporine Versus Azathioprine in the Treatment of Chronic Refractory Urticaria
Fifty six patients of CRU attending the urticaria clinic in the department of Dermatology, Venereology and Leprology at the Post Graduate Institute of Medical Education and Research, Chandigarh will be recruited in the study calculated by using equivalence analysis assuming power of 90%, significance level of 5% and standard deviation of 1 and adjusting 5% of expected drop-outs after taking written informed consent. This study is undertaken with an intention to treat the patients of chronic refractory urticaria completely. Patients will be randomized into two groups A and B using computer generated random number tables, group A will receive Cyclosporine and group B will receive Azathioprine; wherein, 28 random single and double-digit numbers from 1-56 will be selected before recruitment, and patients coming on these numbers will be randomized in a particular group. Random number generation, recruitment and randomization, were all done by the same investigator..
Available definition for chronic refractory urticaria (CRU) is chronic spontaneous urticaria,
with disease duration of at least 6 months or above, which is not controlled with four fold
increased dosage of antihistamines (as per EAACI guidelines), given for at least three
consecutive months and requiring repeated courses of oral corticosteroids. There is no strict
number of oral corticosteroids intake courses before the patient can be labeled as chronic
refractory urticaria.
Study end- points
1. Primary end-point :
Change in urticaria activity score (UAS7) i.e decrease more than 75% from baseline to
week 12 (at end of treatment) within group A and B and comparison between corresponding
groups.
2. Secondary end-points :
1. Change in outcome scoring scale (OSS) from baseline to week 12 within group A and
B.
2. Change in UAS7 and OSS from baseline to week 24 (end of follow-up) within group A
and B.
3. Change in ASST, APST, IgE levels from baseline to week 12 within group A and B.
4. Comparison for the above mentioned parameters between group A and B. Treatment
sessions will be for three months, daily oral cyclosporine and daily oral
azathioprine and after completion, patients will be additionally followed for three
more months.
Oral cyclosporine 3mg/kg/day (200mg/day) will be started and given for one week, if
patient shows improvement, the same dose will be continued for the total study
period ( three months) ,after physical examination and various laboratory testing
most importantly renal function tests, blood pressure monitoring, hemogram and if
no symptomatic improvement then dose of cyclosporine will be increased slowly till
5 mg/kg /day.
Oral azathioprine will be started at 1mg/kg/day ( 50mg/day) for one week , if
patient demonstrates improvement, same dose is continued for the total study period
( 3months), after physical examination and various laboratory testing i.e LFTs,
Hemogram, if no symptomatic improvement then dose of azathioprine will be increased
to 2mg/kg/day (100mg/day).
All the patients will be uniformly started on levocetrizine 10mg/day, which will
continue daily for one month in all patients followed by stopping the drug and
adding only if the patient is symptomatic.
After three months both the drugs will be stopped and levocetrizine (10mg/day) will
be continued for three months of follow up period.
Clinical assessment of patients will be done before the starting of cyclosporine
and azathioprine, and every fortnightly during three months of treatment and during
three months of follow up period. Assessment will be done using UAS7and OSS as
devised by Berroeta et al.
URTICARIA ACTIVITY SCORE Table-2 SCORE WEALS PRURITUS
0 None None
1 Mild (<20 weals / 24 hours) Mild (present but not troublesome)
2 Moderate (20-50 weals / 24 hours) Moderate (troublesome but does not interfere
with sleep)
3 Severe (>50 weals / 24 hours) Severe (sufficiently troublesome to interfere with
normal daily activity and sleep)
Scores of both parameters i.e. number of weals and severity of the pruritus per day
are to be added to get UAS of that day and average UAS over 7 days is calculated
which will range between 0 to 6. Patients will be instructed to write down number
of weals and severity of itching in their daily urticaria diary. UAS7 will be
calculated every fortnightly by calculating average of weal and itch score of the
previous seven days after taking detailed history from patient.
UAS7 SCORES71 HEALTH STATE
0 Urticaria free
1-6 Well controlled urticaria
7-15 Mild urticaria
16-27 Moderate urticaria
26-42 Severe urticaria
OUTCOME SCORING SCALE Another assessment scale i.e.Outcome scoring scale devised by
Berroeta et al 22 for cyclosporine and azathioprine treatment of CU will also be
used for clinical assessment of subjects.
1- No change 2 - Minimal improvement (no change in frequency or extent, symptomatic
improvement ±) 3- Moderate improvement (less frequent or extensive, symptomatic
improvement +) 4- Marked improvement (occasional episodes and less extensive,
symptomatic improvement ++) 5- Clearance
In addition, ASST , APST and IgE levels will be done before starting cyclosporine
and azathioprine and at the completion of the treatment after three months.
FOLLOW UP After completion of oral cyclosporine and oral azathioprine for three
months, patients will be followed up for a period of three more months, every
fortnightly in urticaria clinic. At each visit, clinical assessment will be done
using UAS7 and OSS. Urticaria being a type 1 hypersensitivity reaction, will
relapse immediately as soon as the treatment is withheld. So, a follow up period of
three months will be sufficient enough to study the effect of cyclosporine and
azathioprine on long term remission of urticaria. Patients developing angioedema
and having uncontrolled excessive exacerbation during treatment will be removed
from study and will be treated accordingly.
Patients who will fail to take the treatment for ≥ one week will be defined as
defaulters and removed from the study. Those with no improvement even after one
month of regular treatment will be labelled as non responders.
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