Chronic Pain Clinical Trial
Official title:
ACTsmart - Feasibility of Smart Phone Delivered ACT Treatment for Adults With Longstanding Pain
The aims are to test feasibility and preliminary effects of a smart phone delivered ACT
treatment for adults with longstanding pain.
The hypotheses are that
1. ACTsmart will be a feasible and accessable treatment delivery form
2. ACTsmart will improve function and quality of life
Chronic pain affects 12-30% of the population and often results in depression, disability,
and reduced daily function and quality of life. Medical strategies are often ineffective or
insufficient to alleviate symptoms and increase functioning. Instead, the empirical support
for cognitive behavior therapy (CBT) is today well established, and such interventions are
commonly seen as critically important for patients with chronic pain. However, modest effects
sizes calls for further improvements. Recent developments within CBT, particularly Acceptance
and Commitment Therapy (ACT), have suggested the utility of acceptance and mindfulness
strategies to manage pain and distress. The body of evidence for ACT has grown rapidly during
the past decade, and ACT is today listed by the American Psychological Association as a
treatment for chronic pain, with strong empirical support.
Internet-delivered ACT Despite the increased empirical support for ACT the availability is
still very limited, and a large number of patients do not receive this treatment. In other
domains, the accessibility of empirically supported treatments has increased during the past
decade due to the development of methods to deliver the treatment via internet. For example,
a large number of studies illustrate the utility of internet-delivered CBT for anxiety,
insomnia and depression, with treatment effects similar to those obtained in studies with
face-to-face treatment. Few studies have yet evaluated internet-delivered ACT (iACT) for
chronic pain, but a recent pilot study from our group with participants suffering from
fibromyalgia (n=41) illustrated very promising results that warrant further studies to
evaluate the effects of this treatment.
To make treatment more accessible and present in patients' daily life we will use a smart
phone application to deliver treatment.
Recruitment Patients will be recruited through self referral. Information regarding the study
will be provided through newspapers and social media, as well as in direct communication with
pain clinics and primary care units, including instructions regarding e.g. eligibility and
how to sign up. Once patients have been found eligible and expressed interest in study
participation they will be assessed by a psychologist, and when needed by a pain physician,
via semi-structured interviews to confirm eligibility and to ensure that the patient meet the
study criteria. Informed consent is obtained from all participants prior to the assessment.
Statistical methods Evaluations of treatment effects are primarily based on intent-to-treat
analyses. The statistical approach will primarily be based on linear multilevel modeling
(LMM), which takes into account dependencies between repeated measures and differences
between patients in pre-treatment status and treatment response (i.e. random effects
modeling) and also provide means of handling missing data. More traditional methods, such as
ANOVA and hierarchical regression, may also be utilized when appropriate.
Interviews Evaluations of feasibility and as a base for further development of the smart
phone application will be done via semi structured interviews during and after treatment
period.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01659073 -
Using Perfusion MRI to Measure the Dynamic Changes in Neural Activation Associated With Caloric Vestibular Stimulation
|
N/A | |
Recruiting |
NCT05914311 -
Use of Dermabond in Mitigation of Spinal Cord Stimulation (SCS) Trial Lead Migration
|
N/A | |
Recruiting |
NCT05422456 -
The Turkish Version of Functional Disability Inventory
|
||
Enrolling by invitation |
NCT05422443 -
The Turkish Version of Pain Coping Questionnaire
|
||
Recruiting |
NCT05057988 -
Virtual Empowered Relief for Chronic Pain
|
N/A | |
Completed |
NCT04385030 -
Neurostimulation and Mirror Therapy in Traumatic Brachial Plexus Injury
|
N/A | |
Recruiting |
NCT06206252 -
Can Medical Cannabis Affect Opioid Use?
|
||
Completed |
NCT05103319 -
Simultaneous Application of Ketamine and Lidocaine During an Ambulatory Infusion Therapy as a Treatment Option in Refractory Chronic Pain Conditions
|
||
Completed |
NCT03687762 -
Back on Track to Healthy Living Study
|
N/A | |
Completed |
NCT04171336 -
Animal-assisted Therapy for Children and Adolescents With Chronic Pain
|
N/A | |
Completed |
NCT03179475 -
Targin® for Chronic Pain Management in Patients With Spinal Cord Injury
|
Phase 4 | |
Completed |
NCT03418129 -
Neuromodulatory Treatments for Pain Management in TBI
|
N/A | |
Completed |
NCT03268551 -
MEMO-Medical Marijuana and Opioids Study
|
||
Recruiting |
NCT06060028 -
The Power of Touch. Non-Invasive C-Tactile Stimulation for Chronic Osteoarthritis Pain
|
N/A | |
Recruiting |
NCT06204627 -
TDCS* and Laterality Trainnning in Patients With Chronic Neck Pain
|
N/A | |
Completed |
NCT00983385 -
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics
|
Phase 3 | |
Recruiting |
NCT05118204 -
Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization
|
Phase 4 | |
Terminated |
NCT03538444 -
Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder
|
N/A | |
Not yet recruiting |
NCT05812703 -
Biometrics and Self-reported Health Changes in Adults Receiving Behavioral Treatments for Chronic Pain
|
||
Completed |
NCT05036499 -
PFI for Pain-Related Anxiety Among Hazardous Drinkers With Chronic Pain
|
N/A |