Clinical Trials Logo

Clinical Trial Summary

This is a cohort study in which patients who survive Acute Kidney Injury (AKI) during intensive care unit (ICU) admission are recalled at 3-6 months and renal function tests are performed.

The purpose of the study is describe renal function in AKI survivors at follow-up.

Additional aims are to determine how well admission values of renal function markers perform as predictors of renal function at follow-up and whether estimates of renal function at follow-up differ depending on which renal function marker is used.


Clinical Trial Description

Type of study: Cohort study with prospectively collected clinical data cross-matched with local & national databases.

Source population: Patients suffering from AKI on a mixed intensive care unit, at the Karolinska University Hospital, Solna.

Setting: Single centre, Central Intensive Care unit Karolinska University hospital, Solna, Stockholm from September 2008 and May 2011.

Exposure: AKI on ICU and grade of AKI according to the RIFLE criteria Intervention: none

Outcome: Renal function 3 months after ICU discharge according to creatinine and Cystatin C measurements.

Parameters: Co-morbidities, ICU diagnoses, disease severity score, daily physiological and laboratory parameters, medications administered, interventions RRT (Renal replacement therapy), mechanical intervention, inotropes, surgery.

Data is crossmatched with national registries including the Swedish cause of death register (to obtain dates of death), the Swedish renal register (to obtain details of patients receiving chronic dialysis and with pre-existing Chronic Kidney Disease (CKD) diagnoses. Data is also cross matched with a large local ICU register (Clinisoft) to obtain physiological parameters& intervention details. Clinisoft is also used to obtain risk of death for all ICU patients and all AKI patients (from the source population). Ethical approval has been granted by Stockholm Regional ethical review body (2008-408-32 2008/443-31/1-3, 2010/1780-31-2, 2011-408-32 and 2016-1801-32).

Aims:

1. Describe the incidence of renal dysfunction in terms of Glomerular filtration rate (GFR) under 60ml/min/173m² at 3-6 months follow-up after AKI. According to serum Cystatin C and Creatinine values.

2. Describe the incidence of Acute Kidney Disease (AKD) at 3 month follow-up.

3. Produce a predictive model using comorbidities and admission data to CKD (Chronic Kidney Disease) and AKD 3-6 after AKI in intensive care patients.

4. Examine how estimated GFR using creatinine and Cystatin C differ from measured Iohexol GFR at 6 month follow-up. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02894164
Study type Observational [Patient Registry]
Source Karolinska Institutet
Contact
Status Completed
Phase N/A
Start date January 2008
Completion date December 2014

See also
  Status Clinical Trial Phase
Active, not recruiting NCT02878317 - Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
Recruiting NCT03160326 - The QUALITY Vets Project: Muscle Quality and Kidney Disease
Recruiting NCT02896309 - The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity N/A
Active, not recruiting NCT02756520 - Observational Study on CKD Treatment With a Ketosteril Supplemented Protein-restricted Diet (Keto-024-CNI) N/A
Completed NCT02875886 - DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease Phase 4
Withdrawn NCT02885545 - The Strategy to Prevent Hemorrhage Associated With Anticoagulation in Renal Disease Management (STOP HARM) Trial Phase 4
Recruiting NCT02369549 - Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease Phase 3
Active, not recruiting NCT02992548 - Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease Phase 4
Active, not recruiting NCT02483039 - Nephrologist Follow-up Versus Usual Care After an Acute Kidney Injury Hospitalization N/A
Terminated NCT02543177 - Optimised Procedure in Patients With NSTEMI and CKD N/A
Recruiting NCT02251431 - Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome Phase 3
Recruiting NCT02205944 - Impact of Presurgical Exercise on Hemodialysis Fistula Outcomes N/A
Active, not recruiting NCT02202018 - A Cluster Randomized Trial to Assess the Impact of Patient and Provider Education on Use of Home Dialysis N/A
Active, not recruiting NCT01909115 - Randomized Study of Two Vitamin D Dosing Strategies in Children With Chronic Kidney Disease Phase 3
Active, not recruiting NCT02231138 - Efficacy and Safety of Abelmoschus Manihot for Chronic Kidney Disease Phase 4
Active, not recruiting NCT02492672 - Registry to Evaluate Maintenance Treatment With Venofer in Pediatric Patients With Chronic Kidney Disease N/A
Enrolling by invitation NCT02237352 - Mechanisms of Diabetic Nephropathy in Ecuador N/A
Completed NCT02230202 - Endothelial Microparticles: A Novel Marker of Vascular Dysfunction N/A
Completed NCT02309528 - Chronic Kidney Disease Knowledge and Awareness Among American Indians N/A
Completed NCT02405312 - Shared Decision Making and Renal Supportive Care N/A