Chronic Kidney Disease Clinical Trial
Official title:
KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease
The goals of the KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney
Disease) study are 1) to establish a CKD cohort representing Korean CKD population for up to
10-year follow-up, and 2) to investigate the renal progression, mortality, complications,
risk factors, role of biochemical parameters and the genetic influence.
KNOW-CKD Research Group comprises nephrologists, pediatric nephrologists, epidemiologists and
statisticians from eleven centers in Korea. KNOW-CKD will enroll 2,850 individuals with CKD
stage from 1 to 5 between 2011 and 2015 and follow them up to 10 years. Dialyzed patients or
those with allograft kidney are excluded. At enrollment and at pre-specified intervals,
laboratory tests will be conducted on the kidney function, biochemical profiles, anemia,
cardiovascular complication (echocardiography, coronary CT, arterial stiffness), and mineral
bone disorder. A biobank is also established for the DNA, serum and urine at regular
interval. Information on the medical history, health questionnaires, QoL will also be
collected. Web-based case-report forms (CRF) is developed for the systemic management of the
patient data.
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