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Effect of Teleprevir in Triple Therapy on Intrahepatic Immunological Mechanisms — ETIM  

Chronic Hepatitis C Clinical Trial

Official title:
Effect of Telaprevir in Triple Therapy on Intrahepatic Immunological Mechanisms.

Clinical Trial Summary

Chronic hepatitis C infection (HCV) is a disease that affects worldwide about 170 million people. The previous standard of care therapy of chronic HCV patients consists of pegylated-IFN-α combined with ribavirin, and results in sustained clearance of HCV-RNA in only about 50% of the HCV genotype 1 infected patients. Telaprevir, a NS3A-4A inhibitor, has previously proven to offer therapeutic options to previous non-responders to the standard of care. Although, not all chronic HCV patients benefit from telaprevir and it is still not known why certain patients are also non-responsive to this triple therapy. In this study we try to understand why certain patients are also non-responsive to telaprevir, how triple therapy modulates the responsiveness to IFN-α and what the immunological consequences are of treatment with telaprevir, either directly or as a result of telaprevir-induced reduction of HCV-RNA levels.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01641094
Study type Observational
Source Foundation for Liver Research
Contact
Status Completed
Phase N/A
Start date May 2012
Completion date December 2014
View Details
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