Investigating the Role of Active Versus Chronic Coronary Artery Calcification on Acute Myocardial Infarct

Chest Pain Clinical Trial

— Active-AMI  

Official title:

Investigating the Role of Active Versus Chronic Coronary Artery Calcification on Acute Myocardial Infarct: A Novel Pilot Study Using Sodium-Fluoride Positron Emission Tomography (PET) and Computed Tomography (CT) Techniques

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03712020
• Other study ID #: 2014/2183
• Status: Completed
• Start date: February 2015
• Est. completion date: July 2019

Study information

• Verified date: June 2020
• Source: National Heart Centre Singapore
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigator aims to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart.

The patient cohort will consist of patients diagnosed to have either acute coronary syndrome (ACS) (comprising of either unstable angina pectoris or acute myocardial infarction) or suspected coronary artery disease (CAD). The PET images will be compared to images obtained from standard contrast CT of the coronaries. This study will provide additional insights about active versus non-active calcification amongst patients with ACS or suspected CAD.

Description:

Contemporary techniques used to visualize coronary artery calcification include standard non-contrast computed tomography (CT) of the coronaries measuring amount of calcium deposition in the coronaries, contrast CT and more recently, using sodium-fluoride (Na-F) positron emission tomography (PET) to image coronary and valvular calcification. Na-F has been shown to accumulate in areas of active calcification where contrast CT of the heart has been shown to accumulate in areas of chronic calcification. The investigator aims to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart.

The patient cohort will consist of patients diagnosed to have either acute coronary syndrome (ACS) (comprising of either unstable angina pectoris or acute myocardial infarction) or suspected coronary artery disease (CAD). The PET images will be compared to images obtained from standard contrast CT of the coronaries. This study will provide additional insights about active versus non-active calcification amongst patients with ACS or suspected CAD.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: July 2019
• Est. primary completion date: March 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years to 89 Years

Eligibility

Inclusion Criteria:

• Patients with a diagnosis of acute coronary syndrome

• Patients referred for workup of suspected coronary syndrome

• Able to provide written, informed consent.

• Age between (including) 50 years to 89 years old.

Exclusion Criteria:

• Pregnant & Lactating women

• weight <=180kg

Related Conditions & MeSH terms

• Chest Pain
• Myocardial Infarction

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
National Heart Centre Singapore	Singapore General Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Coronary artery calcification will be determined by Tc-99m MDP SPECT-CT and Na-F PET-CT	Na-F has been shown to accumulate in areas of active calcification where contrast CT of the heart has been shown to accumulate in areas of chronic calcification. We aim to determine the feasibility of understanding the process of active versus chronic calcification using Na-F PET scan and contrast CT scan of the heart.	12 months