Chest Pain Clinical Trial
Official title:
Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?
Cardiovascular disease is the most common cause of mortality and morbidity worldwide.
Recently, a growing body of evidence has identified Vitamin D deficiency as a potential risk
factor for cardiovascular disease. Therefore, there is an increasing interest to explore the
mechanism in which vitamin D deficiency affect the cardiovascular system.
The investigators want to examine the relationship between serum vitamin D levels and the
coagulation status in the subjects. The applied the calibrated automated thrombogram (CAT)
to assess thrombin generation in plasma as a measure of overall thrombotic activity, and
thus to suggest a mechanism that may explain the link between vitamin D deficiency and
cardiovascular disease.
Our study population are going to include 100 patients from the internal departments in Emek
hospital, who present with chest pain but without acute coronary syndrome (ACS). The
investigators will take blood samples from the subjects to measure the serum vitamin D
levels and the generation of thrombin. The patients will be divided into four groups
according to the level of vitamin D to evaluate the effect of vitamin D levels in the blood
on coagulability and thrombotic activity in these patients.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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