Chagas Disease Clinical Trial
Official title:
Validation of Galectin-3 as a Biomarker for Determining Patients Prognosis With Chagas Disease
The purpose of this study is to analyze the efficacy of Galectin-3 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional and laboratory tests.
Previous studies indicate that activated macrophages secrete Galectin-3, a molecule that is
involved in the development of fibrosis and tissue rearrangement in the liver, kidney and the
heart. Its plasmatic levels are increased on patients with acute decompensated heart failure.
These observations suggest that measuring levels of Galectin-3 in patients with cardiac
diseases can be useful to determine their prognosis. To investigate the role of this new
biomarker in Chagas Disease, we will study a Chagas Disease population (including patients
with the indeterminate and cardiac form of the disease). The assessment of the prognostic
value of Galectin-3 will be done through the comparison between its plasmatic levels and each
patients's clinical evaluation, disease severity, inflammatory biomarkers and cardiac
function tests.
The patients included in the study must at first sign the written consent. They shall be
accompanied in the specialized outpatient clinics for Chagas disease - Hospital São Rafael -
Centro de Biotecnologia e Terapia Celular. They will be submitted to several tests,
including:
- Collection of Blood samples for biochemical analysis;
- Electrocardiogram;
- Holter Electrocardiogram;
- Echocardiogram;
- Treadmill Test;
- X-Ray Imaging;
- Magnetic Resonance Imaging;
- Evaluation of the quality of life through the application of questionnaires (SF 36 and
the Minnesota Living With Heart Failure Questionnaire).
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