Cervical Cancer Clinical Trial
Official title:
Efficacy and Safety of Radiotherapy Concurrently Combined With Cisplatin and Nimotuzumab for Patients With Locally Advanced Cervical Cancer
The purpose of this phase II trial is to determine the feasibility and efficacy of nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable locally advanced cervical cancer.
For locally advanced cervical cancer, radical radiation with concurrent chemotherapy remains
the standard treatment recommended by NCCN. However, in more than 35% of cases, tumor
persistence recurrence or metastasis would occur after chemoradiation. Nimotuzumab, belongs
to anti-EGFR monoclonal antibodies, has proved to be useful in multiple solid tumors, such
as NPC, colorectal cancer, etc.
In recent years, nimotuzumab was also applied in recurrence or metastasis cervical cancer.
It was proved to be well tolerated and might have a role in the treatment of advanced
cervical cancer. However, there is no publication about nimotuzumab used in locally advanced
cervical cancer.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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