Cervical Cancer Clinical Trial
Official title:
Phase III Randomized Trial of Comparing Chemoradiotherapy vs. Radiotherapy Alone in Lymph Node Negative Patients With Early-Stage Cervical Cancer Following Radical Hysterectomy
This phase III study is designed to examine if low-risk (lymph node negative), stage I a2-II b cervical cancer patients treated by paclitaxel/cisplatin chemoradiation have greater toxicities but similar survival rate as those treated by radiotherapy alone.
Cervical carcinoma is one of the most common gynecologic cancers worldwide. Concurrent
radiotherapy with cisplatin-based chemotherapy has become the standard treatment for
patients with high risk factors cervical cancer. However, the treatment modality in patients
with low-risk (lymph node negative) is still disputable. It is not yet known whether
cisplatin-based chemoradiotherapy are more effective than radiotherapy alone in treating
these patients.
Therefore, the investigators are going to perform the efficacy and safety study of
postoperative concurrent paclitaxel/cisplatin chemoradiotherapy vs. radiotherapy alone in
lymph node negative patients with early-stage cervical cancer following radical
hysterectomy.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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