Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

Cerebrovascular Disorders Clinical Trial

— iNO  

Official title:

Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy: A Phase I Drug Pilot Research Plan

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05871606
• Other study ID #: IRB00090271
• Status: Not yet recruiting
• Phase: Phase 1
• Start date: June 2024
• Est. completion date: July 2025

Study information

• Verified date: March 2024
• Source: Wake Forest University Health Sciences
• Contact: Anna M Helms, RN
• Phone: 704-446-0473
• Email: Anna.M.Helms[@]atriumhealth.org
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute ischemic (non-bleeding) stroke (AIS).

Description:

This dose escalation phase I study is to evaluate the safety and feasibility of iNO as adjunctive therapy in the treatment of AIS in adult patients with clinically significant strokes.

iNO will act as a selective vasodilator to ischemic tissues in the brain, increasing perfusion to the area of the brain most at risk (penumbra) in AIS patients. This therapy will help to increase collateral circulation and perfusion to the penumbra, salvaging this tissue and limiting the volume of core infarct while mitigating reperfusion injury to the salvaged tissue.

Protection of ischemic penumbra is paramount in IAMT stroke patients. IAMT to re-establish blood flow during AIS from a large vessel occlusion (LVO) reduces death and disability. Initially this intervention was recommended up until 6 hours after symptom onset, but more recently has proven safe and effective up to 16 and 24 hours after stroke onset in select patients. These studies have confirmed the long believed thought that supporting ischemic penumbra during AIS helps limit the size of the ultimate core infarct and therefore reduces disability and death from stroke. Treatment aimed at protecting ischemic penumbra is thus paramount to treatment and research endeavors in AIS patients.

iNO protects ischemic penumbra. Nitric oxide is an endothelial-derived vasodilator and has been shown to mediate cytoprotection after ischemic reperfusion injury and appears to aid in ischemic preconditioning signaling pathways. iNO has been shown to cause selective dilation of arterioles in the ischemic penumbra of stroke and subarachnoid hemorrhage animal models, helping augment the cerebral microcirculation and improve penumbral blood flow. This has been shown to reduce ischemic brain damage, limit core infarct, and consistently improve neurological outcome in a middle cerebral artery AIS mouse model

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 27
• Est. completion date: July 2025
• Est. primary completion date: February 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Age 18 and < 80

• Clinical evidence of acute ischemic (non-bleeding) stroke (AIS) with NIH Stroke Scale of 6 or higher

• Non-contrast Computed tomography (CT) Head with ASPECT (Alberta Stroke Program Early CT) score 6

• Symptom onset began < 16 hours from initiation of intra-arterial mechanical thrombectomy (IAMT) procedure

• CT Angiogram (CTA) evidence of anterior circulation MCA (Middle Cerebral Artery) M1 segment occlusion.

• CT Perfusion (CTP) evidence of core infarct volume of < 70ml and a ratio of ischemic tissue to initial core infarct volume of 1.8 or greater, and an absolute volume of penumbra of 15ml or greater

• Patient or patient's representative provides consent

• Pre-stroke modified Rankin Scale (mRS) of < =2

• General endotracheal anesthesia (GETA) is planned to be used, as standard care, for IAMT

• Treatment with iNO requires mechanical ventilation. Because IAMT can be performed using conscious sedation and not GETA, only those patients for which the procedure is planned with GETA will be included. The decision for the type of anesthetic depends on the severity of stroke, region of brain affected by the stroke, and the ability for the patient to cooperate for the procedure.

Exclusion Criteria:

• Hypotension at presentation, defined as systolic blood pressure (SBP) < 100 or MAP < 60; profound hypertension with SBP >185 or DBP >110mmHg unable to be controlled with IV medications

• Inability to undergo a brain MRI (e.g., implanted pacemaker)

• Patients who received IV tPA >4.5hrs after symptom onset

• Coaguloapathy, defined as platelet count < 50,000, INR >3.0, PTT > 3x normal, use of novel anticoagulants with eGFR < 30ml/min

• Vulnerable Subjects including: mentally ill or incompetent patients, those with diminished decision-making capacity, prisoners, inpatient care for long-term chronic illness, terminally ill, pregnant women, and children

• Any form of hemorrhage on non-contrast CT Head or mass lesion

• Severe head injury within 90 days

• Pre-existing severe neurological/psychiatric disease

• Seizure at stroke onset (unable to assess NIHSS)

• Blood glucose < 50mg/dL or >400mg/dL

• Hemoglobin <7mmol/L

• eGFR < 30ml/min

• Allergy to contrast media

• Presumed septic embolus as source of stroke

• Flow limiting intracranial or extracranial carotid stenosis, or complete carotid occlusion

Related Conditions & MeSH terms

• Cerebrovascular Disorders
• Ischemic Stroke

Intervention

Drug:
• iNO
Inhaled Nitrous Oxide

Locations

Country	Name	City	State
United States	Atrium Health	Charlotte	North Carolina
United States	Carolinas Medical Center	Charlotte	North Carolina

Sponsors (1)

Lead Sponsor	Collaborator
Wake Forest University Health Sciences

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum safe dose of iNO for AIS patients - assessing for reperfusion hemorrhage/symptomatic intracranial hemorrhage (sICH)	To establish a maximum safe dose of iNO for acute ischemic (non-bleeding) stroke (AIS) patients, assessing for reperfusion hemorrhage/symptomatic intracranial hemorrhage (sICH)	Year 2
Secondary	Change in pre-endovascular mechanical thrombectomy (IAMT) and post-IAMT core infarct volume	Core infarct measurement pre/post	Year 2