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Cerebrovascular Accident clinical trials

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NCT ID: NCT04282564 Terminated - Clinical trials for Cerebrovascular Accident

Improvement of Executive Functions With the CO-OP Method in the Adult Subject After Stroke

FéCO-OPSA
Start date: February 24, 2020
Phase: N/A
Study type: Interventional

The research focuses on top-down intervention approaches and more specifically on the Cognitive Orientation to daily Occupational Performance (CO-OP) method in the rehabilitation of executive function disorders in adult post-stroke subjects in chronic phase. The main objective of this study is therefore to improve performance in significant activities of daily living for people with chronic post-stroke dysexecutive disorders.

NCT ID: NCT03599544 Terminated - Stroke Clinical Trials

Rehabilitation Robotics, Cognitive Skills Training and Function

Start date: June 6, 2019
Phase: N/A
Study type: Interventional

This study evaluates the effects of robot-assisted therapy for adults more than 6 months after stroke on upper limb functioning. Half of the participants will receive robot-assisted therapy for the arm affected by stroke, and the other half will receive robot-assisted therapy plus training in how to use the weaker arm during every day activities.

NCT ID: NCT03344562 Terminated - Clinical trials for Cerebrovascular Accident

Cranial Electrical Stimulation (CES) as Treatment for Insomnia in Patients With Subacute Stroke

Start date: February 21, 2017
Phase: N/A
Study type: Interventional

This will be a double blinded randomized clinical trial carried out at Zale-Lipshy and Parkland Hospital Inpatient Rehabilitation Facilities. Acute stroke patients with insomnia, identified by the Insomnia Severity Index (ISI), and who choose to participate in this study will be randomized to CES (Cranial Electrical Stimulation) or sham CES. Patients who do not feel they are getting adequate sleep but want to continue in the study will be given the option to receive the standard of care medication as a rescue starting on the 3rd night. Patients will receive treatment with a Fisher-Wallace CES device or Sham CES. Treatment with CES will be for 20 minutes once a day, and the treatment period will be for 7 days. Patients will be allowed to increase the intensity of the device from the suggested starting point of level 2 if they feel no improvement in sleep on night 1. Groups will be monitored with a wrist worn actigraph that records the patient's activity for the duration of the period of study and provides data on sleep latency, time spent asleep, and sleep efficiency. The outcome measures will be total minutes/hours of sleep, sleep efficiency and subjective reports of drowsiness using the Karolinska Sleepiness Scale. Actigraphic data will be collected 24 hours a day for 7 days. The total length of study will be about 24 months with a target N of 100 consented individuals and 85 participants. Patients will be allowed to exit the study at any time on their own choosing. To minimize loss of subjects, patients will have the option to choose SOC rescue starting on the third night. Patients who choose the SOC rescue will continue to be monitored with an actigraph for data collection purposes. The investigator should discontinue study participation for a given subject or withdraw the subject from study if he/she believes that continuation would be detrimental to the subject's well-being. A subject can decide to withdraw from the study at any time and for any reason.

NCT ID: NCT01808261 Terminated - Clinical trials for Cerebrovascular Accident

Proof of Concept (POC) in Patients With Ischaemic Stroke

Start date: May 18, 2013
Phase: Phase 2
Study type: Interventional

Study MAG104615, a Proof of Concept Study for GSK249320 versus placebo in Stroke Patients.

NCT ID: NCT01705353 Terminated - Stroke, Acute Clinical Trials

The Role of HMGB-1 in Chronic Stroke

Start date: September 2012
Phase: N/A
Study type: Observational

The purpose of this study is to measure the presence of HMGB-1 and other proteins in the blood across five time points after stroke, and to determine if their presence correlates with rate of stroke recovery.

NCT ID: NCT01062698 Terminated - Clinical trials for Cerebrovascular Accident

Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy in Acute Ischemic Stroke

THRACE
Start date: June 2010
Phase: N/A
Study type: Interventional

THRACE is a controled, multicenter and randomized trial. The primary objective of this study is to determine whether a combined approach intravenous thrombolysis (IV) + Mechanical thrombectomy is superior to the reference treatment with IV thrombolysis alone, in the 3 hours of onset of symptoms in patients with occlusion of proximal cerebral arteries and with a neurological impairment accident (National Institutes of Health Stroke Scale [NIHSS] ≥ 10). The second objective is to determine the cost-effectiveness of this procedure compared to the standard (IV thrombolysis). The assumption is that the combined approach, by improving the clinical outcome and speed recovery, allows for lower overall costs to the IV thrombolysis in 3 months and less than or at worst neutral to 1 year.

NCT ID: NCT00906477 Terminated - Clinical trials for Cerebrovascular Accident

Norwegian Constraint-Induced (CI) Therapy Multisite Trial

NORCIMT
Start date: October 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether modified CI therapy treatment is suitable and effective in the early rehabilitation after stroke, and to compare early CI intervention with a later CI intervention group.

NCT ID: NCT00847704 Terminated - Stroke Clinical Trials

Clinic-Based AMES Treatment of Stroke

Start date: April 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The hypothesis of this study is that chronic stroke survivors, more than one year post-stroke, with a motor problems in the lower extremity will be able to walk and move the affected leg better after 30 treatments with a new robotic therapy device, the AMES device. The device rotates the ankle while vibrators stimulate the tendons attached to muscles that move the ankle. Testing will be done before, during and after the treatments to determine response to the therapy.

NCT ID: NCT00600184 Terminated - Stroke Clinical Trials

Clinic-Based AMES Treatment of Stroke

AMES
Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The AMES device a investigational device which cyclically rotates the ankle while muscle vibrators stimulate sensory receptors in the muscles opposite to the joint being rotated. In effect, the device provides assisted movement of a joint and enhanced sensation of that movement. The purpose of this study is to determine whether stroke survivors who remain unable to move normally more than one year after their stroke will be able to walk and move their affected leg significantly better after treatment with a new robotic therapy, the AMES device.

NCT ID: NCT00396058 Terminated - Clinical trials for Cerebrovascular Accident

The Effect of Methylphenidate on Motor Learning in Stroke Patients

Start date: November 2006
Phase: Phase 4
Study type: Interventional

The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.