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Carotid Stenosis clinical trials

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NCT ID: NCT03764306 Terminated - Stroke, Ischemic Clinical Trials

New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis

Start date: May 1, 2015
Phase: N/A
Study type: Interventional

Background and purpose. Even if periprocedural cerebral microembolism associated with carotid endarterectomy or stenting usually does not manifest as clinically overt stroke, neuropsychological disturbances resulting from these events represent an important clinical and socioeconomic problem. Still, it remains unclear whether the use proximal protection can lower the incidence of cerebral embolism associated with the treatment of carotid stenosis. Materials and methods. This was a prospective randomised single-centre study, which was aimed at comparison of surgical eversion endarterectomy with stenting under proximal protection in symptomatic patients. The investigators evaluated the incidence of new ischaemic lesions revealed by the diffusion-weighted magnetic resonance imaging 2-4 days after the treatment and neurologic events.

NCT ID: NCT01968226 Terminated - Carotid Stenosis Clinical Trials

TRACER RGD-K5 Carotid Plaque Imaging Study

Start date: November 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the ability of the compound[F-18]RGD-K5, when used as a tracer during PET (positron emission tomography) imaging, to detect regions of unstable atherosclerotic plaque in the carotid artery of subjects being considered for carotid endarterectomy (CEA),and to confirm this ability through histological studies of samples of carotid artery plaques that will be collected during the planned carotid surgery.

NCT ID: NCT01602471 Terminated - Carotid Stenosis Clinical Trials

[F-18] RGD-K5 Positron Emission Tomography (PET) in Participants With Carotid Artery Stenosis

Start date: May 2012
Phase: Phase 2
Study type: Interventional

This trial will be the first trial for the Investigation Product (IP), [F-18]RGD-K5 for carotid plaque imaging and will be conducted as a Phase II trial since this compound has already been tested in humans for phase I and phase II imaging. All study results will be evaluated and analyzed in order to consider the design for future clinical trials.

NCT ID: NCT01599195 Terminated - Carotid Stenosis Clinical Trials

Use of Amplified Sound Signal to Identify Presence of Carotid and Femoral Stenosis

Start date: April 2010
Phase: N/A
Study type: Observational

The purpose of the study is to test a new amplified stethoscope(AudioDoc) that can detect the presence of bruit by using an acoustic signal to represent the bruit. This pilot study will address two questions: is there a detectable difference in recorded sound signal of carotid and femoral bruit when compared to sound signals captured when there is no bruit present; is the use of a visual recorded signal more accurate in identifying carotid and femoral bruit when compared to traditional auscultation with a regular stethoscope and ultrasound.

NCT ID: NCT01415648 Terminated - Clinical trials for Internal Carotid Stenosis

Medico-economic Evaluation of Preoperative Cerebral Oximetry Monitoring During Carotid Endarterectomy

Start date: April 2011
Phase: Phase 3
Study type: Interventional

In France, in 2007, 17 000 patients underwent carotid endarterectomy. The risk of having an ipsilateral postoperative stroke after carotid endarterectomy remains at 1-1.5%. There is no consensus concerning the best cerebral monitoring and hemodynamic optimisation during carotid cross-clamping. The objective of this prospective, multicentric, double-blinded and randomized study is to evaluate the interest of continuous cerebral oximetry monitoring by INVOS™ cerebral oximeter to direct the hemodynamic optimisation during carotid endarterectomy and reduce the new-onset of postoperative radiological (MRI) ischemic lesions. A cost/effectiveness analysis will be conducted to estimate the impact of this monitoring versus standard care on direct and indirect postoperative costs during 120 days. A substudy will evaluate the effect of this monitoring on neurocognitive outcome and on a serum marker of brain injury, protein S-100B

NCT ID: NCT01236508 Terminated - Stroke Clinical Trials

Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease

Start date: November 2010
Phase: Phase 4
Study type: Interventional

The investigators hypothesize that inflammation in carotid plaque is predictive of the extent of ischemic lesion burden on the brain and will add to risk stratification for individuals with carotid disease.

NCT ID: NCT00805311 Terminated - Stroke Clinical Trials

Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis

Start date: April 2009
Phase: Phase 4
Study type: Interventional

The aim of this study is to determine whether optimal medical treatment can postpone carotid endarterectomy.

NCT ID: NCT00742612 Terminated - Carotid Stenosis Clinical Trials

Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy

Start date: February 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine, in patients undergoing carotid endarterectomy, the effect of ARC1779 Injection on the number of microembolic signals detected by transcranial Doppler immediately after surgery. This study will also evaluate the safety of ARC1779 Injection with respect to bleeding risk in patients in the peri-operative (during surgery) period.

NCT ID: NCT00597545 Terminated - Diabetes Clinical Trials

Effect of Raised CBF During CEA on Cognition in DM Patients

Start date: March 2007
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if we can reduce the incidence of cognitive dysfunction — difficulty in performing certain pencil-paper, memory, finger dexterity and thinking type of tasks called neuropsychometric tests — in patients with adult onset diabetes mellitus (DM) undergoing surgery on the carotid artery (CEA). We hypothesize that cognitive dysfunction can be decreased in patients with type II DM by augmenting cerebral blood flow with a shunt during carotid endarterectomy compared to patients with Type II DM who are treated with "conventional" management in which a shunt is placed only if the electroencephalogram (EEG) indicates cerebral ischemia.

NCT ID: NCT00478673 Terminated - Carotid Stenosis Clinical Trials

Post-Approval Study of the NexStent Carotid Stent System and the FilterWire EZ Embolic Protection System: SONOMA

Start date: May 2007
Phase: Phase 4
Study type: Interventional

The primary objective of the SONOMA Registry is to confirm the safety of the NexStent® Carotid Stent System and FilterWire EZ™ Embolic Protection System in routine clinical practice and to identify rare or unanticipated device-related events that might occur.