Cardiovascular Diseases Clinical Trial
Official title:
Activation of the Innate Immune System and Vascular Inflammation in Patients With Type 1 Diabetes
Hyperglycemia is a well-known cardiovascular risk factor. It has also been shown that
episodes of hyperglycemia increase the risk for cardiovascular diseases despite return to
normoglycemia, a phenomenon termed 'glycemic or metabolic memory'. The molecular mechanism
underlying this phenomenon remains unclear.
Cardiovascular events, such as myocardial infarction and stroke are caused by
atherosclerosis, which is characterized by low grade inflammation of the vascular wall,
including accumulation of innate immune cells such as monocytes and macrophages.
The investigators hypothesize that chronic hyperglycemia shifts intracellular metabolism of
innate immune cells towards glycolysis and changes the epigenetic state of (progenitors of)
innate immune cells (monocytes and macrophages), which reprograms these cells towards a more
aggressive, pro-atherogenic phenotype, thereby accelerating atherosclerosis.
In this study, the investigators aim to test this hypothesis. This research will reveal
whether the innate immune cells of patients with chronic hyperglycemia show a durable shift
in intracellular metabolism and epigenetic changes and whether this associates with vascular
inflammation.
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