Cancer Clinical Trial
Official title:
Finnish Vitamin D Trial (FIND)
The Finnish Vitamin D Trial (FIND) is a randomized, double-blind, placebo-controlled, 5-year
supplementation study of the benefits and risks of vitamin D in the primary prevention of
cardiovascular (CVD) and cancer among 18000 men 60 years or older and women 65 years or
older.
[Edit 25.3.2015: Due to difficulties in recruitment and funding, the study size is
approximately 2500 subjects, with a 550 subject subgroup with more detailed examinations]
The participants will be randomized to 3 groups with 6000 in each, with daily supplementation
of either: 1) 40 µg/day (1600 IU) of vitamin D3, 2) 80 µg/day (3200 IU) of vitamin D3, or 3)
placebo.
[Edit 15.3.2015: The 2500 subjects are randomized in 3 groups, approximately 830 subjects per
group.]
Compliance, use of non-study drugs or supplements, diet, development of endpoints, and CVD
and cancer risk factors will be assessed by questionnaires. Blood samples will be collected
for assessment of effect modification by baseline 25-hydroxyvitamin D, as well as for future
ancillary studies of genetic/biochemical hypotheses. Event data will be obtained by record
linkage from the national computerized hospitalization registry.
More detailed description available upon request. ;
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