Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients

Status Completed

Clinical Trial Summary

End-stage renal disease (ESRD) patients often develop cardiovascular complications, and cardiovascular disease is the leading cause of death in this population. Ranolazine's ability to treat angina without reducing heart rate or blood pressure makes it an important option for ESRD patients. The hemodialysis clearance of ranolazine is unknown. A single-dose pharmacokinetic study is needed to characterize ranolazine and its metabolites in ESRD patients on and off hemodialysis. Results of the proposed study will provide initial dosing estimates for a follow-up, multiple-dose pharmacokinetic study in this population.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01435174
Study type	Interventional
Source	University of Michigan
Contact
Status	Completed
Phase	Phase 4
Start date	October 2011
Completion date	March 2013

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