Cardiovascular Diseases Clinical Trial
Official title:
Circulating Endothelial Cell and Endothelial Progenitor Cell Evaluation of Kidney Transplant Patients
We believe that certain cells in the human body (Circulating Endothelial Cells and Endothelial Progenitor Cells) are related to risk of cardiovascular disease. It may be possible to measure levels of these cells in patients who have had a kidney transplant and predict their risk of developing cardiovascular disease.
Coronary disease is one of the most common causes of morbidity and mortality in patients
with known chronic renal insufficiency and those with end stage renal disease. Consequently,
early detection with markers such as circulating endothelial cells and endothelial
progenitor cells has been studied in order to identify vascular function and assess overall
cardiovascular risk. Based on current research, there exists a notable increase in
Circulating Endothelial Cells (CEC) and a reduction of Endothelial Progenitor Cells (EPC)
with renal dysfunction due to endothelial damage. Therefore circulating endothelial cells
are a marker for cardiovascular health.
Renal transplant patients also possess a higher cardiovascular risk than the general
population, but have known improvement in survival as compared to patients with ESRD (End
Stage Renal Disease). In addition, because of the excellent outcomes, graft and patient
survival and even acute rejection are no longer very useful endpoints for clinical studies.
The tolerability of transplant drug regimens and the impact of these regimes on
cardiovascular health in kidney transplantation has become, consequently, a new focus of
research. Currently, no clear long-term analysis has been fulfilled analyzing CEC or EPC in
this group of patients. We hypothesize that CEC can serve as biological markers for
cardiovascular risk assessment in cadaveric and living renal transplant patients. We
eventually hope measurement of these cells can serve as an endpoint in determining
cardiovascular outcome in renal transplant patients. Our present study is aimed to get an
initial assessment of the kinetics of CEC and EPC in renal transplant recipients just prior
to transplant and for the first two years post transplant.
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Observational Model: Cohort, Time Perspective: Prospective
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