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AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding — APACHE  

Cardiac Surgery Clinical Trial

Official title:
AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding

Clinical Trial Summary

In this before-after multicenter study the authors tested the hypothesis that the prophylactic use of aprotinin compared to tranexamic acid could reduce the proportion of patients presenting severe perioperative bleeding.

Clinical Trial Description

Perioperative bleeding remains a real challenge for physicians managing cardiac surgical patients. In patients at high risk for excessive bleeding the prophylactic use of antifibrinolytics may be useful. This study propose to compare the efficacity and innocuity of aprotinin and tranexamic acid to reduce the proportion of patient presenting severe peri-operative bleeding according the Universal Definition of Perioperative Bleeding (UDPB) classification. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04804345
Study type Observational
Source University Hospital, Bordeaux
Contact
Status Completed
Phase
Start date March 31, 2021
Completion date August 31, 2021
View Details
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