Clinical Trials Logo
NCT number NCT03306017
Study type Interventional
Source University Hospital, Toulouse
Contact Pierre SIE, MD, PhD
Phone 05 61 32 22 89
Email sie.p@chu-toulouse.fr
Status Not yet recruiting
Phase N/A
Start date October 2017
Completion date February 2019

Clinical Trial Summary

To compare in vivo platelet and leukocyte activation and phenotype before and after Left ventricular assist device (LAVD) implantation


Clinical Trial Description

The present study plan to investigate platelet activation in vivo using a variety of biomarkers previously identified as sensitive to high shear stress in patients with severe aortic valve stenosis before and after trans arterial valve replacement. As one of the best biomarker is a high degree of platelet-leukocyte interactions, the study will study in parallel leukocytes activation/differentiation. These parameters will be compared at 3 time-points, before and after LAVD implantation in ambulatory patients.


Study Design


Related Conditions & MeSH terms