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Clinical Trial Summary

Lidocaine, local anesthetic used for more than five decades, is being intravenously administered aiming at managing pain in different types of surgeries with promising results. Opioid-induced hyperalgesia need to be considered in ear-nose-throat (ENT) surgery owing to the difficulty of locoregional anesthesia and high level of opioid consumption.

This randomized study aims to compare quality of perioperative analgesia after infusion of intravenous lidocaine during carcinological ENT surgery. The main purpose of this study is to evaluate morphine consumption during the 48 postoperative hours.

Others purposes are evaluation of peroperative remifentanil consumption, morphine consumption during the 24 postoperative hours, chronic post-surgical pain evaluated from 3 to 6 months after carcinologic ENT surgery, and incidence of side effects that can be attributed to lidocaine infusion.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02894710
Study type Interventional
Source Hospices Civils de Lyon
Contact Grégoire Wallon
Email Gregoire.WALLON@lyon.unicancer.fr
Status Recruiting
Phase Phase 3
Start date December 2016
Completion date June 2019