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Dose Escalation of Hypofractionated Radiation Therapy in Patients With Metastatic Cancer

Cancer Clinical Trial

Official title:
A Study of Dose Escalation of Hypofractionated Radiation Therapy in Patients With Metastatic Cancer

Clinical Trial Summary

Patients with metastatic cancer are generally treated with chemotherapy, which has improved median survival compared to best supportive care. Despite this, patients continue to have persistent disease at sites that were initially involved with cancer. Radiation therapy is an effective modality for treating localized cancer but generally has been only used for palliation of symptoms once a patient develops metastatic disease. Since patients often have persistent disease after chemotherapy, the goal of this trial is to use increasing doses of radiation therapy to all sites of involved disease in order to determine the safety and efficacy of hypofractionated radiation therapy.

The purpose of this study is to establish a maximum tolerated dose, dose-limiting toxicities, and recommended phase 2 dose of hypofractionated radiation therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01215500
Study type Interventional
Source University of Chicago
Contact
Status Completed
Phase Phase 1
Start date January 2005
Completion date March 2018
View Details
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