Cancer Clinical Trial
— E²-RADIatEOfficial title:
E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
| NCT number | NCT03818503 |
| Other study ID # | EORTC-1811 |
| Secondary ID | |
| Status | Recruiting |
| Phase | |
| First received | |
| Last updated | |
| Start date | June 24, 2019 |
| Est. completion date | April 30, 2024 |
The primary objective is the collection of real-world data of cancer patients treated with radiotherapy, to support radiotherapy research and to provide evidence of the role of radiation oncology in a multidisciplinary approach. This is an open ended prospective non-interventional non-therapeutic multi-cohort study.
| Status | Recruiting |
| Enrollment | 2000 |
| Est. completion date | April 30, 2024 |
| Est. primary completion date | April 30, 2024 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 12 Years and older |
| Eligibility | Inclusion Criteria: - Pathologically confirmed cancer. - Written informed consent for E²-RADIatE according to applicable legal and ethical requirements - Planned use of radiotherapy - Eligibility of the patient confirmed for at least one cohort confirmed - Patients of 12 years and older |
| Country | Name | City | State |
|---|---|---|---|
| Austria | Medical University of Graz - Radio-oncology | Graz | |
| Austria | Ordensklinikum Linz-Barmherzige Schwestern | Linz | |
| Austria | Universitaetskliniken der Uni Wien - Universitaetsklinikum Wien - AKH unikliniken | Vienna | |
| Belgium | Onze Lieve Vrouw Ziekenhuis | Aalst | |
| Belgium | Cliniques Universitaires Saint-Luc | Brussels | |
| Belgium | Universitair Ziekenhuis Gent | Gent | |
| Belgium | AZ Groeninge Kortrijk - Campus Kennedylaan | Kortrijk | |
| Belgium | U.Z. Leuven - Campus Gasthuisberg | Leuven | |
| Belgium | CHU Site Sainte-Elisabeth-UCL Namur | Namur | |
| Belgium | AZ Turnhout - Campus Sint Elisabeth | Turnhout | |
| Belgium | GasthuisZusters Antwerpen - Sint-Augustinus | Wilrijk | |
| Czechia | University Hospital Hradec Kralove | Hradec Kralove | |
| France | Clinique Pasteur-Lanroze (1174) | Brest | |
| Germany | Universitaetsklinikum Aachen AOR - Medizinische Fakultaet der RWTH | Aachen | |
| Germany | Klinikum Bayreuth Gmbh | Bayreuth | |
| Germany | Universitaetsklinikum Carl Gustav Carus | Dresden | |
| Italy | Ospedale S. Donato, USL -8 | Arezzo | |
| Italy | Azienda Ospedaliero-Universitaria Careggi | Firenze | |
| Italy | Istituto Clinico Humanitas | Milan | |
| Italy | IRCCS Ospedale San Raffaele | Milano | |
| Italy | Istituto Europeo di Oncologia | Milano | |
| Italy | Sacro Cuore Hospital | Negrar | |
| Italy | Centro Nazionale di Adroterapia Oncoloica par il trattamento dei tumori | Pavia | |
| Italy | Istituti Clinici Scientifici Maugeri | Pavia | |
| Italy | Policlinico Universitario Campus Bio-Medico- Oncology Center | Roma | |
| Italy | Universita Di Torino | Torino | |
| Netherlands | Stichting Catharina Ziekenhuis | Eindhoven | |
| Netherlands | Radboudumc - Radboud University Medical Center Nijmegen | Nijmegen | |
| Netherlands | Radiotherapiegroep Arnhem | Nijmegen | |
| Slovenia | The Institute Of Oncology | Ljubljana | |
| Spain | ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia) | Badalona | |
| Spain | Hospital De La Santa Creu I Sant Pau | Barcelona | |
| Spain | Hospital Universitari Vall d'Hebron -Vall d'Hebron Institut Oncologia | Barcelona | |
| Spain | Hospital General Universitario Santa Lucia | Cartagena | |
| Spain | Hospital Universitario Reina Sofia | Cordoba | |
| Spain | Hospital Universitario de La Princesa | Madrid | |
| Spain | Hospital Universitario San Carlos | Madrid | |
| Spain | Complejo Hospitalario de Navarra | Pamplona | |
| Spain | Hospital Universitario de Salamanca (430) | Salamanca | |
| Spain | Hospital Universitario La Fe | Valencia | |
| Switzerland | Inselspital | Bern | |
| Switzerland | Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie | Geneve | |
| Switzerland | Reseau Hospitalier Neuchatelois - RHNe - La Chaux de Fonds | La Chaux-de-Fonds | |
| Switzerland | Hopital du Valais - Hopital de Sion | Sion | |
| Switzerland | UniversitaetsSpital Zurich | Zürich | |
| United Kingdom | NHS Grampian - Aberdeen Royal Infirmary | Aberdeen | |
| United Kingdom | The Christie NHS Foundation trust - The Christie NHS Foundation Trust | Manchester | |
| United Kingdom | Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital | Sheffield |
| Lead Sponsor | Collaborator |
|---|---|
| European Organisation for Research and Treatment of Cancer - EORTC |
Austria, Belgium, Czechia, France, Germany, Italy, Netherlands, Slovenia, Spain, Switzerland, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Number of patients treated with radiotherapy enrolled in the program | 5 years | ||
| Secondary | Disease free survival | 5 years | ||
| Secondary | Loco-regional control | 5 years | ||
| Secondary | Distant metastasis free survival | 5 years | ||
| Secondary | Overall survival | 5 years | ||
| Secondary | Incidence of adverse events related to radiotherapy | 5 years |
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