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Clinical Trial Summary

This is a first in human study to identify whether FP-1305 is suitable to use in humans. The previous pre-clinical studies have demonstrated that FP-1305 binds to a receptor known as CLEVER-1. CLEVER-1 has been shown to support tumour growth. No significant adverse events were witnessed in primates and the dose used will be 300 fold lower than the dose provided to primates which showed no toxicity.

The patients with advanced melanoma, ovarian, pancreatic, colorectal or liver cancer who have exhausted all licenced therapeutic options will die due to their disease. Based on the investigator's existing data CLEVER-1 is expressed in these tumour types. Inhibition of CLEVER-1 with FP-1305 may have an anti-tumour effect in these patients.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03733990
Study type Interventional
Source Faron Pharmaceuticals Ltd
Contact Matti Karvonen, MD, PhD
Phone 02 469 5151
Email matti.karvonen@faron.com
Status Recruiting
Phase Phase 1/Phase 2
Start date December 3, 2018
Completion date November 30, 2024

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