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AZD6738 & Gemcitabine as Combination Therapy — ATRiUM  

Cancer Clinical Trial

Official title:
A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Ascending Doses of Combined Therapy With ATR Inhibitor AZD6738 and Gemcitabine, Using a Model Based Design.

Clinical Trial Summary

A dose escalation trial to assess the safety of AZD6738 in combination with gemcitabine in participants with advanced solid tumours.

Clinical Trial Description

A phase 1, non-randomised, multicentre, model-based dose escalation trial. This trial will assess the safety, tolerability, pharmacokinetics and preliminary anti-tumour activity of ascending doses of combined therapy with ATR inhibitor (AZD6738) and gemcitabine, in participants with advanced solid tumours, followed by an expansion phase in participants with advanced pancreatic ductal adenocarcinoma (PDAC). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03669601
Study type Interventional
Source Cambridge University Hospitals NHS Foundation Trust
Contact Early Phase Team, Cambridge Clinical Trials Unit - Cancer Theme
Phone 01223216083
Email cctuep@addenbrookes.nhs.uk
Status Recruiting
Phase Phase 1
Start date October 15, 2019
Completion date September 30, 2024
View Details
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