Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03503838 |
Other study ID # |
STUDY00004303 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
September 23, 2016 |
Est. completion date |
June 12, 2017 |
Study information
Verified date |
February 2022 |
Source |
Arizona State University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF) are chronic
Philadelphia negative myeloproliferative neoplasms (MPNs) that are characterized by clonal
proliferation of hematopoietic stem cells, intramedullary fibrosis, and splenomegaly. While
disease manifestations may vary amongst the spectrum of MPNs, quality of life considerations
including fatigue, concentration difficulties, pain, sleep disturbance, and depression are
negatively affected in most MPN patients. Inflammation has been suggested to be involved in
the development of disease-related symptoms. Specific pro-inflammatory cytokines (e.g., IL-1,
IL-6, IL-8, and TNF-α) have been associated with particular patient-reported symptoms,
including fatigue, abdominal complaints, microvascular symptoms, and constitutional symptoms.
Pharmacologic therapy can positively impact MPN related symptoms, specifically with JAK
inhibition, however, these treatments often come with negative side effects (e.g., anemia,
thrombocytopenia). Much opportunity remains for improving MPN symptoms (i.e., fatigue,
insomnia, loss of muscle mass, and debilitation) and quality of life.
Yoga, a gentle form of meditative exercise, has been shown to improve symptom management and
quality of life parameters in cancer patients and may be effective in improving MPN-related
symptoms. Here we propose a study evaluating the efficacy of an online yoga intervention
comparing a yoga group to a wait-list control group for improving symptom burden and quality
of life in MPN patients. Secondarily, we plan to evaluate the feasibility of collecting
potential biomarkers that are related to MPN disease-related activity, such as fatigue (i.e.,
cortisol and serum cytokines).
Description:
Participants will be recruited nationally utilizing internet-based strategies, including
social media (i.e., Facebook, Twitter), social networking sites, online and email listervs,
and by contacting MPN patients that were not included in prior feasibility work but expressed
their interest in future work. The research team will provide flyers to recruitment contacts
to provide a description of the study.
MPN patients that expressed interest in future studies will be contacted via email to be
asked of their interest in the current study. A flyer will be provided in the email.
Prospective organizations will be contacted via email and/or phone and asked to advertise the
study by posting the provided recruitment information (e.g., flyers, blurbs) to social media
sites and/or websites, emailing listservs, or displaying flyers at location. National
organizations agreeing to advertise for the study will be sent recruitment information (e.g.,
flyers, blurbs) via email, and local organizations will have the option for hand delivery or
email. Interested MPN patients will complete an eligibility screening using a Qualtrics link.
The eligibility screening takes 5-10 minutes to complete.
If ineligible, the participant will be sent an email notification and will be offered a
discounted monthly membership to online yoga streaming (Udaya.com). If eligible, the
potential participant will be emailed to schedule a time for an intake appointment. The
intake appointment will provide greater details pertaining to the study, review of the
consent process, and address participant questions.
After completing the intake appointment, the participant will be directed to an informed
consent page (individual link using Qualtrics) with details concerning the requirements of
the study, as well as potential risks and benefits. There will be a place for the participant
to type in their electronic signature, which will constitute their consent to participate in
the study. After receipt of the signed consent form, the participant will be mailed a Fitbit.
They will be instructed to wear the Fitbit for one week to collect baseline physical
activity. After one week of wear, the participant will be directed to a Qualtrics link to
complete baseline self-report measures. At this point, the participant will be randomized
into either the wait-list control group or the yoga group via a web-based randomization tool.
Yoga Group: The intervention will be 12-weeks in duration and will consist of a series of
pre-approved online yoga classes. MPN patients will be asked to complete a minimum of 60
minutes per week of yoga practice with encouragement to do more if they can. All Udaya.com
videos will include a proper warm-up, cool down, and closing mindfulness activity (i.e.,
message from yoga therapist, brief meditation, final relaxation). A 12-week yoga prescription
utilized in prior feasibility work will be improved and modified for this study. The 12-week
yoga prescription was designed to be safe and progressive for this specific population.
Modifications to the prescription will be made based on qualitative feedback received from
patients that participated in prior feasibility work. During the intervention, all classes
will offer alternative poses, modifications, and use of props (i.e., yoga blocks and straps)
in the instance poses are difficult for the participant (i.e., painful, irregular, uneven
breath) and to ensure safety. In addition to specific instruction regarding form and safety,
the yoga therapist will provide descriptions of each video that includes tips and
modifications to poses (e.g., set the knee on your yoga mat if this feels more comfortable
for you). Additionally, patients will also receive a yoga modifications handout outlining the
contraindicated yoga poses with modifications. This handout will include an exercise warning
for patients that experience dizziness, lightheadedness or faintness, excessive shortness of
breath, chest pain, and that they need to stop the activity and contact their health care
professional immediately if these symptoms are experienced.
Wait-List Control Group: The control group will be asked to maintain their usual level of
activity for 16 weeks before being given access to the yoga intervention. Once study
participants in the yoga group have completed all outcome measures up through the 4-week
follow-up (week 16), participants in the control group will be allowed to participate in the
same online yoga prescription that was provided to the yoga group.